Structure of PDB 7k5u Chain A Binding Site BS02

Receptor Information
>7k5u Chain A (length=577) Species: 1422 (Geobacillus stearothermophilus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AFTLADRVTEEMLADKAALVVEVVEENYHDAPIVGIAVVNEHGRFFLRPE
TALADPQFVAWLGDETKKKSMFDSKRAAVALKWKGIELCGVSFDLLLAAY
LLDPAQGVDDVAAAAKMKQYEAVRPDEAVYGKGAKRAVPDEPVLAEHLVR
KAAAIWALERPFLDELRRNEQDRLLVELEQPLSSILAEMEFAGVKVDTKR
LEQMGEELAEQLRTVEQRIYELAGQEFNINSPKQLGVILFEKLQLPVLKK
TKTGYSTSADVLEKLAPYHEIVENILHYRQLGKLQSTYIEGLLKVVRPDT
KKVHTIFNQALTQTGRLSSTEPNLQNIPIRLEEGRKIRQAFVPSESDWLI
FAADYSQIELRVLAHIAEDDNLMEAFRRDLDIHTKTAMDIFQVSEDEVTP
NMRRQAKAVNFGIVYGISDYGLAQNLNISRKEAAEFIERYFESFPGVKRY
MENIVQEAKQKGYVTTLLHRRRYLPDITSRNFNVRSFAERMAMNTPIQGS
AADIIKKAMIDLNARLKEERLQARLLLQVHDELILEAPKEEMERLCRLVP
EVMEQAVTLRVPLKVDYHYGSTWYDAK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7k5u Following replicative DNA synthesis by time-resolved X-ray crystallography.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		N527 N529 S530 K532 S585 T586 L610 T611 Q612 T613 R615 S617 S618 T619 E620 N622 G711 Y714 G720 N724 R771 F786 Q797
Binding residue
(residue number reindexed from 1)		N228 N230 S231 K233 S286 T287 L311 T312 Q313 T314 R316 S318 S319 T320 E321 N323 G412 Y415 G421 N425 R472 F487 Q498
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0004518 nuclease activity
GO:0008408 3'-5' exonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006281 DNA repair
GO:0006302 double-strand break repair
GO:0006974 DNA damage response
GO:0071897 DNA biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7k5u, PDBe:7k5u, PDBj:7k5u
PDBsum7k5u
PubMed33976175
UniProtE1C9K5

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