Structure of PDB 7jsn Chain A Binding Site BS02

Receptor Information
>7jsn Chain A (length=820) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EVEKFLDSNVSFAKQYYNLRYRAKVISDLLGPREAAVDFSNYHALNSVEE
SEIIFDLLRDFQDNLQAEKCVFNVMKKLCFLLQADRMSLFMYRARNGIAE
LATRLFNVHKDAVLEECLVAPDSEIVFPLDMGVVGHVALSKKIVNVPNTE
EDEHFCDFVDTLTEYQTKNILASPIMNGKDVVAIIMVVNKVDGPHFTEND
EEILLKYLNFANLIMKVFHLSYLHNCETRRGQILLWSGSKVFEELTDIER
QFHKALYTVRAFLNCDRYSVGLLDMTKQKEFFDVWPVLMGEAPPYAGPRT
PDGREINFYKVIDYILHGKEDIKVIPNPPPDHWALVSGLPTYVAQNGLIC
NIMNAPSEDFFAFQKEPLDESGWMIKNVLSMPIVNKKEEIVGVATFYNRK
DGKPFDEMDETLMESLTQFLGWSVLNPDTYELMNKLENRKDIFQDMVKYH
VKCDNEEIQTILKTREVYGKEPWECEEEELAEILQGELPDADKYEINKFH
FSDLPLTELELVKCGIQMYYELKVVDKFHIPQEALVRFMYSLSKGYRRIT
YHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHDIDHRGTN
NLYQMKSQNPLAKLHGSSILERHHLEFGKTLLRDESLNIFQNLNRRQHEH
AIHMMDIAIIATDLALYFKKRTMFQKIVDQSKTYETQQEWTQYMMLDQTR
KEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLQQNP
IPMMDRNKADELPKLQVGFIDFVCTFVYKEFSRFHEEITPMLDGITNNRK
EWKALADEYETKMKGLEEEK
Ligand information
Ligand IDVDN
InChIInChI=1S/C23H32N6O4S/c1-5-8-20-24-16(4)21-23(30)25-22(26-29(20)21)18-15-17(9-10-19(18)33-7-3)34(31,32)28-13-11-27(6-2)12-14-28/h9-10,15H,5-8,11-14H2,1-4H3,(H,25,26,30)
InChIKeySECKRCOLJRRGGV-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0CCCc1nc(c2n1NC(=NC2=O)c3cc(ccc3OCC)S(=O)(=O)N4CCN(CC4)CC)C
CACTVS 3.341CCCc1nc(C)c2n1NC(=NC2=O)c3cc(ccc3OCC)[S](=O)(=O)N4CCN(CC)CC4
ACDLabs 10.04O=C2N=C(Nn1c(nc(c12)C)CCC)c3cc(ccc3OCC)S(=O)(=O)N4CCN(CC)CC4
FormulaC23 H32 N6 O4 S
Name2-{2-ETHOXY-5-[(4-ETHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-5-METHYL-7-PROPYLIMIDAZO[5,1-F][1,2,4]TRIAZIN-4(1H)-ONE;
VARDENAFIL, LEVITRA
ChEMBLCHEMBL1520
DrugBankDB00862
ZINCZINC000018324776
PDB chain7jsn Chain A Residue 904 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7jsn Structure of the Visual Signaling Complex between Transducin and Phosphodiesterase 6.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		Q773 F776
Binding residue
(residue number reindexed from 1)		Q766 F769
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.4.35: 3',5'-cyclic-GMP phosphodiesterase.
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
GO:0004117 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity
GO:0048101 calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity
Biological Process
GO:0007165 signal transduction
GO:0007601 visual perception
GO:0019933 cAMP-mediated signaling
GO:0060041 retina development in camera-type eye
Cellular Component
GO:0001750 photoreceptor outer segment
GO:0005886 plasma membrane
GO:0042622 photoreceptor outer segment membrane
GO:0042995 cell projection
GO:0097381 photoreceptor disc membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7jsn, PDBe:7jsn, PDBj:7jsn
PDBsum7jsn
PubMed33007200
UniProtP11541|PDE6A_BOVIN Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Gene Name=PDE6A)

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