Structure of PDB 7jsj Chain A Binding Site BS02

Receptor Information
>7jsj Chain A (length=468) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SFVILFVTPLLLLPLVILMPAKFVRCAYVIILMAIYWCTEVIPLAVTSLM
PVLLFPLFQILDSRQVCVQYMKDTNMLFLGGLIVAVAVERWNLHKRIALR
TLLWVGAKPARLMLGFMGVTALLSMWISNTATTAMMVPIVEAILQQRKRL
CKAMTLCICYAASIGGTATLTGTGPNVVLLGQMNELFPDSKDLVNFASWF
AFAFPNMLVMLLFAWLWLQFVYMRSKKNEKAALKVLQEEYRKLGPLSFAE
INVLICFFLLVILWFSRDPETKYVSDATVAIFVATLLFIVPSQKPKFYPP
PLLDWKVTQEKVPWGIVLLLGGGFALAKGSEASGLSVWMGKQMEPLHAVP
PAAITLILSLLVAVFTECTSNVATTTLFLPIFASMSRSIGLNPLYIMLPC
TLSASFAFMLPVATPPNAIVFTYGHLKVADMVKTGVIMNIIGVFCVFLAV
NTWGRAIFDLDHFPDWAN
Ligand information
Ligand IDNA
InChIInChI=1S/Na/q+1
InChIKeyFKNQFGJONOIPTF-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Na+]
FormulaNa
NameSODIUM ION
ChEMBL
DrugBankDB14516
ZINC
PDB chain7jsj Chain A Residue 603 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7jsj Structure and inhibition mechanism of the human citrate transporter NaCT.
Resolution3.12 Å
Binding residue
(original residue number in PDB)		S136 I139 S140 N141 G226
Binding residue
(residue number reindexed from 1)		S124 I127 S128 N129 G172
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005343 organic acid:sodium symporter activity
GO:0005515 protein binding
GO:0015137 citrate transmembrane transporter activity
GO:0015141 succinate transmembrane transporter activity
GO:0015142 tricarboxylic acid transmembrane transporter activity
GO:0015293 symporter activity
GO:0015370 solute:sodium symporter activity
GO:0017153 sodium:dicarboxylate symporter activity
GO:0022857 transmembrane transporter activity
Biological Process
GO:0006814 sodium ion transport
GO:0006842 tricarboxylic acid transport
GO:0015729 oxaloacetate transport
GO:0015741 fumarate transport
GO:0015742 alpha-ketoglutarate transport
GO:0015744 succinate transport
GO:0015746 citrate transport
GO:0035674 tricarboxylic acid transmembrane transport
GO:0035725 sodium ion transmembrane transport
GO:0055085 transmembrane transport
GO:0071285 cellular response to lithium ion
GO:0071422 succinate transmembrane transport
GO:1903825 organic acid transmembrane transport
Cellular Component
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7jsj, PDBe:7jsj, PDBj:7jsj
PDBsum7jsj
PubMed33597751
UniProtQ86YT5|S13A5_HUMAN Na(+)/citrate cotransporter (Gene Name=SLC13A5)

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