Structure of PDB 7jlg Chain A Binding Site BS02

Receptor Information
>7jlg Chain A (length=268) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MNRKWEAKLKQIEEREEPPSIWRLFHRQAQAFNFVKSCKEDVHVFALECK
VGDGQRIYLVTTYAEFWFYYKSRKNLLHCYEVIPENAVCKLYFDLEFNKP
ANPGADGKKMVALLIEYVCKALQELYGVNCSAEDVLNLDSSTDEKFSRHL
IFQLHDVAFKDNIHVGNFLRKILQPALDLLPDLSFLVVKNNMGEKHLFVD
LGVYTRNRNFRLYKSSKIGKRVALEVTEDNKFFPIQSKDVSDEYQYFLSS
LVSNVRFSDTLRILTCEP
Ligand information
Ligand IDDTP
InChIInChI=1S/C10H16N5O12P3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(25-7)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H,22,23)(H2,11,12,13)(H2,17,18,19)/t5-,6+,7+/m0/s1
InChIKeySUYVUBYJARFZHO-RRKCRQDMSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3C[C@@H]([C@H](O3)CO[P@](=O)(O)O[P@@](=O)(O)OP(=O)(O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[CH]3C[CH](O)[CH](CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)O3
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3CC(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[C@H]3C[C@H](O)[C@@H](CO[P@@](O)(=O)O[P@](O)(=O)O[P](O)(O)=O)O3
ACDLabs 10.04O=P(O)(O)OP(=O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)CC3O
FormulaC10 H16 N5 O12 P3
Name2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
ChEMBLCHEMBL335538
DrugBankDB03222
ZINCZINC000008215662
PDB chain7jlg Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7jlg Structural basis of DNA synthesis opposite 8-oxoguanine by human PrimPol primase-polymerase.
Resolution2.07 Å
Binding residue
(original residue number in PDB)		R76 Y100 D114 E116 K165 S167 R288 N289 R291 K297
Binding residue
(residue number reindexed from 1)		R56 Y80 D94 E96 K145 S147 R208 N209 R211 K217
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.102: DNA primase AEP.
2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003887 DNA-directed DNA polymerase activity
GO:0003896 DNA primase activity
Biological Process
GO:0006269 DNA replication, synthesis of primer
GO:0042276 error-prone translesion synthesis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7jlg, PDBe:7jlg, PDBj:7jlg
PDBsum7jlg
PubMed34188055
UniProtQ96LW4|PRIPO_HUMAN DNA-directed primase/polymerase protein (Gene Name=PRIMPOL)

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