Structure of PDB 7h4t Chain A Binding Site BS02

Receptor Information
>7h4t Chain A (length=140) Species: 31704 (Coxsackievirus A16) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SGAIYVGNYRVVNRHLATHNDWANLVWEDSSRDLLVSSTTAQGCDTIARC
DCQTGVYYCSSRRKHYPVSFSKPSLIFVEASEYYPARYQSHLMLAVGHSE
PGDCGGILRCQHGVVGIVSTGGNGLVGFADVRDLLWLDEE
Ligand information
Ligand ID5SH
InChIInChI=1S/C11H9N/c1-2-4-10(5-3-1)11-6-8-12-9-7-11/h1-9H
InChIKeyJVZRCNQLWOELDU-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.385
OpenEye OEToolkits 2.0.4		c1ccc(cc1)c2ccncc2
FormulaC11 H9 N
Name4-phenylpyridine
ChEMBLCHEMBL109074
DrugBank
ZINCZINC000000967333
PDB chain7h4t Chain A Residue 202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7h4t Group deposition for crystallographic fragment screening of Coxsackievirus A16 (G-10) 2A protease
Resolution1.69 Å
Binding residue
(original residue number in PDB)		V62 H71 I113 R115
Binding residue
(residue number reindexed from 1)		V56 H65 I107 R109
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.28: picornain 3C.
3.4.22.29: picornain 2A.
3.6.1.15: nucleoside-triphosphate phosphatase.
Gene Ontology
Molecular Function
GO:0008233 peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0016032 viral process

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Molecular Function
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Biological Process
External links
PDB RCSB:7h4t, PDBe:7h4t, PDBj:7h4t
PDBsum7h4t
PubMed
UniProtQ65900|POLG_CX16G Genome polyprotein

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