Structure of PDB 7fsf Chain A Binding Site BS02

Receptor Information
>7fsf Chain A (length=1102) Species: 243274 (Thermotoga maritima MSB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AVNSKYHHSCINCGGLNTDERNERGLPCEVCLPEDSPSDIYRALLERKTL
KEYRFYHEFWNEYEDFRSFFKKKFGKDLTGYQRLWAKRIVQGKSFTMVAP
TGVGKTTFGMMTALWLARKGKKSALVFPTVTLVKQTLERLQKLADEKVKI
FGFYSSMKKEEKEKFEKSFEEDDYHILVFSTQFVSKNREKLSQKRFDFVF
VDDVDAVLKASRNIDTLLMMVGIPEEIIRKAFSTIKQGKIYERPKNLKPG
ILVVSSATAKPRGIRPLLFRDLLNFTVGRLVSVARNITHVRISSRSKEKL
VELLEIFRDGILIFAQTEEEGKELYEYLKRFKFNVGETWSEFEKNFEDFK
VGKINILIGVQAYYGKLTRGVDLPERIKYVIFWGTPSMRFSLELDKAPRF
VLARVLKEMGLIKAQENPDVEELRKIAKEHLTQKEFVEKVKEMFRGVVVK
DEDLELIIPDVYTYIQASGRSSRILNGVLVKGVSVIFEEDEEIFESLKTR
LLLIAEEEIIEEAEANWKELVHEVEESRRRSERELTDTSRSLLIIVESPT
KAETLSRFLGRASSRKERNIIVHEAVTGEGVILFTATRGHVYDLVTKGGI
HGVEEENGKFVPVYNSLKRCRDCGYQFTEDRDECPVCSSKNIDDKTETLR
ALREISLEADEILVATDPDVEGEKISWDVTQYLLPSTRSLRRIEMHEITR
YGFKKARESVRFVDFNLVKAQIVRRVQDRWIGFELSGKLQKRFGRSNLSA
GRVQSTVLGWIVEREEEYKKSEKDFTLLVLENGVNLEVEGKIADDVVTVV
ELQEAEEEKNPLPPYTTSSALSEISQKLRLGVQEVMDILQDLFEKGFITF
HRTDSTRISLEGQNVARTYLRKIGKEDIFMGRSWSTEGAHEAIRPVKPID
ARELEEMIEEGLIADLTKKHLRVYELIFNRFLASQSAAVKVKKQIVTVDV
DGKRMGIEQIVEILRDGWNLFVPLTVSPRFEHRTYKIKEKKFYKKHTVPL
FTQASIVEEMKKRGIGRPSTYAKIVEVLFRRGYVYEDKYKRVRPTRFGVM
VYSYLKERYEKYVTEETTRRLEEIMDKVERGEEDYQATLRLLYEEIKSLM
EE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7fsf Chain A Residue 1202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7fsf Structure of reverse gyrase with a minimal latch that supports ATP-dependent positive supercoiling without specific interactions with the topoisomerase domain.
Resolution2.77 Å
Binding residue
(original residue number in PDB)		C11 C14 C29 C32
Binding residue
(residue number reindexed from 1)		C10 C13 C28 C31
Annotation score1
Enzymatic activity
Enzyme Commision number 5.6.2.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003916 DNA topoisomerase activity
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
GO:0008094 ATP-dependent activity, acting on DNA
GO:0008270 zinc ion binding
GO:0016887 ATP hydrolysis activity
GO:0046872 metal ion binding
GO:0160097 reverse gyrase activity
Biological Process
GO:0006265 DNA topological change
GO:0006268 DNA unwinding involved in DNA replication
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7fsf, PDBe:7fsf, PDBj:7fsf
PDBsum7fsf
PubMed37204816
UniProtO51934|RGYR_THEMA Reverse gyrase (Gene Name=rgy)

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