Structure of PDB 7fav Chain A Binding Site BS02

Receptor Information
>7fav Chain A (length=269) Species: 11044 (Rubella virus vaccine strain RA27/3) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PRGCQGCELCRYTRVTNDRAYVNLWLERDRGATSWAMRIPEVVVYGPEHL
ATHFPLNHYSVLKPAEVRPPRGMCGSDMWRCRGWQGVPQVRCTPSNAHAA
LCRTGVPPRVSTRGGELDPNTCWLRAAANVAQAARACGAYTSAGCPRCAY
GRALSEARTHKDFAALSQRWSASHADASSDGTGDPLDPLMETVGCACSRV
WVGSEHEAPPDHLLVSLHRAPNGPWGVVLEVRARPEGGNPTGHFVCAVGG
GPRRVSDRPHLWLAVPLSR
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7fav Chain A Residue 1410 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7fav Crystal structure of the Rubella virus protease reveals a unique papain-like protease fold.
Resolution1.64 Å
Binding residue
(original residue number in PDB)		C1175 C1178 C1225 C1227
Binding residue
(residue number reindexed from 1)		C145 C148 C195 C197
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity

View graph for
Molecular Function
External links
PDB RCSB:7fav, PDBe:7fav, PDBj:7fav
PDBsum7fav
PubMed35835220
UniProtO40955|POLN_RUBVR Non-structural polyprotein p200

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