Structure of PDB 7f9p Chain A Binding Site BS02

Receptor Information
>7f9p Chain A (length=483) Species: 5811 (Toxoplasma gondii) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MVTAKKDENFSEWYTQAIVRSEMIEYYDISGCYIMRPWAFHIWEKVQRFF
DDEIKKMGVENSYFPMFVSRHKLEKEVAWVTHYGDSPLPEKIAIRPTSET
IMYPAYAKWIRSHRDLPLKLNQWCSVVRWEFKQPTPFLRTREFLWQEGHT
AHATEEEAWELVLDILELYRRWYEECLAVPVIKGEKSEGEKFAGGKKTTT
VEAFIPENGRGIQAATSHLLGTNFAKMFEIEFEDEEGHKRLVHQTSWGCT
TRSLGVMIMTHGDDKGLVIPPRVASVQVVIIPILFKDENTGEILGKCREL
KTMLEKADIRVRIDDRSNYTPGWKYNHWEVKGVPLRLELGPKDLAKGTAR
VVRRDTGEAYQISWADLAPKLLELMEGIQRSLFEKAKARLHEGIEKISTF
DEVMPALNRKHLVLAPWCEDPESEEQIKKETQKLSEIQAIEAGMTGAMKT
LCIPFDQPPMPEGTKCFYTGKPAKRWTLWGRSY
Ligand information
Ligand ID02A
InChIInChI=1S/C4H7NO2/c6-4(7)3-1-2-5-3/h3,5H,1-2H2,(H,6,7)/t3-/m0/s1
InChIKeyIADUEWIQBXOCDZ-VKHMYHEASA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.0C1CN[C@@H]1C(=O)O
OpenEye OEToolkits 1.7.0C1CNC1C(=O)O
CACTVS 3.370OC(=O)[CH]1CCN1
CACTVS 3.370OC(=O)[C@@H]1CCN1
ACDLabs 12.01O=C(O)C1NCC1
FormulaC4 H7 N O2
Name(2S)-azetidine-2-carboxylic acid
ChEMBLCHEMBL1165239
DrugBank
ZINCZINC000001698540
PDB chain7f9p Chain A Residue 902 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7f9p TgPRS with double inhibitors
Resolution1.57 Å
Binding residue
(original residue number in PDB)		T439 E441 W487 F534 H560 W589
Binding residue
(residue number reindexed from 1)		T97 E99 W145 F192 H218 W247
Annotation score3
Enzymatic activity
Enzyme Commision number 6.1.1.15: proline--tRNA ligase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004827 proline-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006433 prolyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7f9p, PDBe:7f9p, PDBj:7f9p
PDBsum7f9p
PubMed
UniProtA0A7J6JUK2

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