Structure of PDB 7ela Chain A Binding Site BS02

Receptor Information
>7ela Chain A (length=1402) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEEDIACVKDLVSKYLANNERLSRQKLAFLVQTEPRMLLMEGLKLLSLCI
EVDSCNANGCEHNSEDKSVERILHDHGVLTPSLCFVVPDGYKLTGNVLIL
LECFVRSSPANFEQKYVEDFKKLEQLKEDLKSVDINLIPLIDGRTSFYNE
QIPDWVNDKLRDTLFSLLKYAQESNSLFEESEYSRLCESLSMTESLNALL
DNRSNHYEEVIASCHQGINNKLTAHEVKLQIEEEYQVFRNRLRKGEIEGQ
FLKVEKNQLLNEFNNLYADKVAEKDSVEHLTHQFKRASPILRFLYANISE
CQMQCWRSFLNKVKSMRILNTRRKLLLIFDALILLASKHDQVRKKPLRGW
LGTCFVSVNDRLVSLESTKKDLKKWVERRQQVECPSKNQILNSIFQKTIS
KATTALRDVGISVDHYKIDMEVICPDGYDLIMDFDVSGVTPTISYQRSEE
EAFPYIMGDVDLLKTTDLERLSSLSLALVNSMKTSSTVKEAYCQEFSLGE
TEFQLIYQKTGECSKCYAINDNRVGEVCSFYADPKRYFPAIFSAEVLQTT
VSTMISWIEDCNELEEQLDKIRSLTKMILILILAHPSKRSQKLLQNLRYF
IMAYVSDYYHKDLIDKVREELITDVEFLLYRLLRTLMGLVLSEDVKSMMT
NRFKFILNISYMCHFITKETPDRLTDQIKCFEKFLEPKVKFGHVSINPAD
TATEEELDDMVYNAKKFLSKGGCTSAKGPSYKKPGVSKKYLSLLTSSFNN
GSLFKQESPQSYNSVGPDTGRLKFSLSYKEQVGGNRELYIGDLRTKMFTR
LIEDYFEALSSQLSGSCLNNEKEFENAILSMKLNVSMAHVSYSMDHSKWG
PMMCPFLFLTVLQNLIFLSIKGRDYLSTLLMWHMHKMVEIPFNVVSAMMK
SFIKAQLGTKQSITEDFFYSNFQIGVVPSHISSILDMGQGILHNTSDFYA
LITERFINYAISCVCGGTIDAYTSSDDQISLFDQTLTELLHRDPEEFRAL
MEFHYYMSDQLNKFVSPKSVIGRFVAEFKSRFFVWGDEVPLLTKFVAAAL
HNIKCKEPHQLAETIDTIVDQSVANGVPVHLCNLIQIRTLSLLQYARYPI
DPFLLNCETDVRDWVDGNRSYRIMRQIEGLIPDACSKIRSMLRRLYNRLK
TGQLHEEFTTNYLSSEHLSSLKNLCELLGVEPPSESDLEYSWLNLAAHHP
LRMVIPTIVKTIQNSSIASGFVGLCRTLGSKCVRGPNKENLYIKSIQSLI
TGTQGIELLTNSIGVQYWRVPLGLRNKSESVVSYFRPLLWDYMCISLSTA
IELGAWVLGDPKTTNPCDYFPLKPTASKLLEDRVGLNHIIHSLRRLYPSV
FEKHILIKFLDLCVALDVNCEALSLVSHIVKWKREEHYIVLSSELRFSHT
RT
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain7ela Chain A Residue 2400 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7ela Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		D1192 D1334 E1384
Binding residue
(residue number reindexed from 1)		D845 D977 E1027
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.1.-.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0016787 hydrolase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0019079 viral genome replication
GO:0039689 negative stranded viral RNA replication
GO:0039694 viral RNA genome replication
GO:0039696 RNA-templated viral transcription
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0044423 virion component

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7ela, PDBe:7ela, PDBj:7ela
PDBsum7ela
PubMed34127846
UniProtA0A097F4L1

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