Structure of PDB 7el9 Chain A Binding Site BS02

Receptor Information
>7el9 Chain A (length=1731) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DEYVQELKGLIRKHEFGHQKVTFLSQSPLLTEGFKLLSSLVELESCEAHA
CQADGFKLTGKTLILLETFVRVNPDEFEKKWKADMSKLLNLKHDLQKTLV
PIVDGRSNYNNRFVADWVIERIRWLLIEILKASEDQEYQRLIHSLSNVKN
QSLGLENLEHLKRNSLDYDERLNESLFIGLKGDIRESTVREELIKLKLWF
KDEVFSKGLGKFKLTDRRELLESLSSLGAHLDSDVSSCPFCNNKLMEIVY
NVTFSCVERTDTHSNIEKHYLSVLSLCNKIKGLKVFNTRRNTLLFLDLIM
VNLMVDISDSCQDAIESLRKSGLIVGQMVMLVNDRVLDILEAVKLIRKKI
GTNPNWVKNCSKILERSHPEIWHHLSTLIKQPDFNSLISIAQHLVSDRPI
MRYSVKICRHKLFQEMSSFEQMRLFKTLSSISLSLINSMKTSFSSRLLVN
EYFGNVRLRECYAQRFYLAESLVGFLFYQKTGERSRCYSVYLSDNGVMSE
QGSFYCDPKRFFLPVFSDEVLAGMCEEMTSWLDFDTGLMNDTGPILRLLV
LAILCSPSKRNQTFLQGLRYFLMAFANQIHHIDLTSKLVVECKSSSEVVV
QRLAVGLFIRLLSGESDASLFFSRRFKYLLNVSYLCHLITKETPDRLTDQ
IKCFEKFIEPKVKFGCAVVNPSLNGKLTVDQEDIMINGLKKFFSKSLRDT
EDVQTPGVCKELLNYCVSLFNRGKLKVSGELKNNPFRSPTEFTSISSNSG
NLKFGLSYKEQVGSNRELYVGDLNTKLMTRLVEDFSEAVGNSMKYTCLNS
EKEFERAICDMKMAVNNGDLSCSYDHSKWGPTMSPALFLALLQMLELRTP
VDRSKIDLDSVKSILKWHLHKVVEVPINVAEAYCIGTSLSEEFFHQTMQL
NGQIPSHIMSVLDMGQGILHNTSDLYGLITEQFLCYALDLLYDVIPVSYT
SSDDQITLIKTPSDAAEWLEMICFHEFLSSKLNKFVSPKSVIGTFVAEFK
SRFFVMGEETPLLTKFVAAALHNVKCKTPTQLSETIDTICDQCIANGVST
KIVTRISKRVNQLIRYSGYGETPFGAIEDQDVKDWVDGSRGYRLQRKIEA
IFHDDKETSFIRNCARKVFNDIKRGRIFEENLINLIGRGGDEALTGFLQY
AGCSEQEVNRVLNYRWVNLSSFGDLRLVEEVPTLIKTLQSKLSRQSSVAS
GFIGFCKSMGSKCVRDGKGGFLYIKEVYSGVSACTCEICALKPKIIYCNN
SLNKVSQFSKPILWDYFSLVLTNACELGEWVFSTVKEPQKPLNNQNFFWA
VKPKVVRQIEDQLGMNHVLQSIRRNYPVLFDEHLTPFMNDLQVSRTMDSG
RLKFLDVCIALDMMNENLGIISHLLKTRDNSVYIVKQSDCALAHIRQSSY
TDWELGLSPQQICTNFKTQLVLSSMVNPLVLSTSCLKSFFWFNEVLELED
DSQIELAELTDFALMVKNQNVSRAMFVEDIAMGYVVSNFEGVRISLSNVM
VDGVQLPPQDIGELFGLKAGLVVQIDHVRMSTKFKLKRKMVYSFSLECIM
DVGEIQNKEVILKVVAVDQSVSGSGGNHMLLDGVSVVASLPLFTGQASFD
LAAMLIESNLAGSNDNFLMRNVTLDLGGFSPELSDKYSYRLSGPENQEDP
LVLKDGAFYVGGERLSTYKVEFTGDLVVKALGALEDDESVVSMLHQLWPY
LKATSQVILFQQEDFTIVHDLYKKQLTKSIE
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain7el9 Chain A Residue 2301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7el9 Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		D1188 D1330 E1381
Binding residue
(residue number reindexed from 1)		D825 D954 E998
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.1.-.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0019079 viral genome replication
GO:0039689 negative stranded viral RNA replication
GO:0039694 viral RNA genome replication
GO:0039696 RNA-templated viral transcription
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0044423 virion component

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7el9, PDBe:7el9, PDBj:7el9
PDBsum7el9
PubMed34127846
UniProtQ6IVU0

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