Structure of PDB 7ef9 Chain A Binding Site BS02

Receptor Information
>7ef9 Chain A (length=414) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QASVSPYHLFSDVADVTAFRSNLLSWYDQEKRDLPWRNLAKEEANSDRRA
YAVWVSEVMLQQTQVATVIDYYTRWMQKWPKLQDLASASLEEVNQLWSGL
GYYSRGRRLQEGARKVVEELGGHMPRTAETLQQLLPGVGRYTAGAIASIA
FDQVTGVVDGNVLRVLCRVRAIGADPTSTLVSHHLWNLAQQLVDPARPGD
FNQAAMELGATVCTPQRPLCSHCPVQSLCRAYQRVQRGQLSEECALNTRQ
CQLCLTSSSPWDPSMGVANFPRKASRRPPREEYSATCVVEQPGAIGGPLV
LLVQRPDSGLLAGLWEFPSVTLEPSEQHQHKALLQELQRWCGPLPAIRLQ
HLGEVIHIFSHIKLTYQVYSLALDQAPASTAPPGARWLTWEEFCNAAVST
AMKKVFRMYEDHRQ
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7ef9 Structure of the mammalian adenine DNA glycosylase MUTYH: insights into the base excision repair pathway and cancer.
Resolution1.97 Å
Binding residue
(original residue number in PDB)		L108 Q109 Q110 Q112 V113 R156 G185 G187 Y189 T190 D207 G208 N209 R212 R332
Binding residue
(residue number reindexed from 1)		L60 Q61 Q62 Q64 V65 R108 G137 G139 Y141 T142 D159 G160 N161 R164 R276
Enzymatic activity
Catalytic site (original residue number in PDB) E105 Y189 D207
Catalytic site (residue number reindexed from 1) E57 Y141 D159
Enzyme Commision number 3.2.2.31: adenine glycosylase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0019104 DNA N-glycosylase activity
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006284 base-excision repair

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Molecular Function
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Biological Process
External links
PDB RCSB:7ef9, PDBe:7ef9, PDBj:7ef9
PDBsum7ef9
PubMed34142156
UniProtQ99P21|MUTYH_MOUSE Adenine DNA glycosylase (Gene Name=Mutyh)

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