Structure of PDB 7ef8 Chain A Binding Site BS02

Receptor Information
>7ef8 Chain A (length=402) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SVSPYHLFSDVADVTAFRSNLLSWYDQEKRDLPWRNLAKEEANSDRRAYA
VWVSEVMLQQTQVATVIDYYTRWMQKWPKLQDLASASLEEVNQLWSGLGY
YSRGRRLQEGARKVVEELGGHMPRTAETLQQLLPGVGRYTAGAIASIAFD
QVTGVVDGNVLRVLCRVRAIGADPTSTLVSHHLWNLAQQLVDPARPGDFN
QAAMELGATVCTPQRPLCSHCPVQSLCRAYQRVQEECACQLCLTSSSPWD
PSMGVANFPRKASRRPPREEYSATCVVEQPGAIGGPLVLLVQRPDSGLLA
GLWEFPSVTLEPSEQHQHKALLQELQRWCGPLPAIRLQHLGEVIHIFSHI
KLTYQVYSLALDQAPASTAPPGARWLTWEEFCNAAVSTAMKKVFRMYEDH
RQ
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7ef8 Structure of the mammalian adenine DNA glycosylase MUTYH: insights into the base excision repair pathway and cancer.
Resolution2.45 Å
Binding residue
(original residue number in PDB)		L108 Q109 Q110 Q112 V113 R156 G185 G187 Y189 T190 D207 G208 N209 R212 P263 K329
Binding residue
(residue number reindexed from 1)		L58 Q59 Q60 Q62 V63 R106 G135 G137 Y139 T140 D157 G158 N159 R162 P213 K261
Enzymatic activity
Catalytic site (original residue number in PDB) E105 Y189 D207
Catalytic site (residue number reindexed from 1) E55 Y139 D157
Enzyme Commision number 3.2.2.31: adenine glycosylase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0019104 DNA N-glycosylase activity
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006284 base-excision repair

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Molecular Function
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Biological Process
External links
PDB RCSB:7ef8, PDBe:7ef8, PDBj:7ef8
PDBsum7ef8
PubMed34142156
UniProtQ99P21|MUTYH_MOUSE Adenine DNA glycosylase (Gene Name=Mutyh)

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