Structure of PDB 7ea8 Chain A Binding Site BS02

Receptor Information
>7ea8 Chain A (length=101) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GGVMKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDL
RFQSAAIGALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRG
E
Ligand information
>7ea8 Chain J (length=122) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
tgcctggagactagggagtaatccccttggcggttaaaacgcgggggaca
gcgcgtacgtgcgtttaagcggtgctagagctgtctacgaccaattgagc
ggcctcggcaccgggattctcg
Receptor-Ligand Complex Structure
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PDB7ea8 Cryo-EM structure of SETD2/Set2 methyltransferase bound to a nucleosome containing oncohistone mutations.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		R40 P43 V46 R63 R83
Binding residue
(residue number reindexed from 1)		R8 P11 V14 R31 R51
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0030527 structural constituent of chromatin
Cellular Component
GO:0000786 nucleosome

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Molecular Function
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Cellular Component
External links
PDB RCSB:7ea8, PDBe:7ea8, PDBj:7ea8
PDBsum7ea8
PubMed33972509
UniProtQ6PI79|H33_XENLA Histone H3.3

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