Structure of PDB 7e7s Chain A Binding Site BS02

Receptor Information
>7e7s Chain A (length=1020) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MENAHTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAEEGKTLL
ELVIEQFEDLLVRILLLAACISFVLAWFEEGEETITAFVEPFVILLILVA
NAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDI
VEIAVGDKVPADIRLTSIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAV
NQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQ
QKLDEFGEQLSKVISLICIAVWIINIGHFNDPVHGGSWIRGAIYYFKIAV
ALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICS
DKTGTLTTNQMSVCRMFILDRVEGDTCSLNEFTITGSTYAPIGEVHKDDK
PVNCHQYDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVE
KMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTP
NKPSSMSKMFVKGAPEGVIDRCTHIRVGSTKVPMTSGVKQKIMSVIREWG
SGSDTLRCLALATHDNPLRREEMHLEDSANFIKYETNLTFVGCVGMLDPP
RIEVASSVKLCRQAGIRVIMITGDNKGTAVAICRRIGIFGQDEDVTSKAF
TGREFDELNPSAQRDACLNARCFARVEPSHKSKIVEFLQSFDEITAMTGD
GVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAI
YNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLLWVNLVTDGLP
ATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYLAIGCYVGAATVGAAA
WWFIAADGGPRVSFYQLSHFLQCKEDNPDFEGVDCAIFESPYPMTMALSV
LVTIEMCNALNSLSENQSLLRMPPWENIWLVGSICLSMSLHFLILYVEPL
PLIFQITPLNVTQWLMVLKISLPVILMDETLKFVARNYLEGISWPFVLLI
MPLVIWVYSTDTNFSDMFWS
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain7e7s Chain A Residue 4002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7e7s Cryo-EM analysis provides new mechanistic insight into ATP binding to Ca 2+ -ATPase SERCA2b.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		N767 E770 T798 D799 E907
Binding residue
(residue number reindexed from 1)		N765 E768 T796 D797 E905
Annotation score5
Enzymatic activity
Enzyme Commision number 7.2.2.10: P-type Ca(2+) transporter.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0005215 transporter activity
GO:0005388 P-type calcium transporter activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0019899 enzyme binding
GO:0044325 transmembrane transporter binding
GO:0044548 S100 protein binding
GO:0046872 metal ion binding
GO:0086039 P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential
GO:0106222 lncRNA binding
Biological Process
GO:0000045 autophagosome assembly
GO:0002026 regulation of the force of heart contraction
GO:0006816 calcium ion transport
GO:0006874 intracellular calcium ion homeostasis
GO:0006984 ER-nucleus signaling pathway
GO:0007155 cell adhesion
GO:0008544 epidermis development
GO:0010460 positive regulation of heart rate
GO:0010666 positive regulation of cardiac muscle cell apoptotic process
GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling
GO:0014883 transition between fast and slow fiber
GO:0014898 cardiac muscle hypertrophy in response to stress
GO:0016240 autophagosome membrane docking
GO:0032469 endoplasmic reticulum calcium ion homeostasis
GO:0032470 positive regulation of endoplasmic reticulum calcium ion concentration
GO:0033292 T-tubule organization
GO:0034220 monoatomic ion transmembrane transport
GO:0034599 cellular response to oxidative stress
GO:0034976 response to endoplasmic reticulum stress
GO:0045822 negative regulation of heart contraction
GO:0070050 neuron cellular homeostasis
GO:0070296 sarcoplasmic reticulum calcium ion transport
GO:0070588 calcium ion transmembrane transport
GO:0086036 regulation of cardiac muscle cell membrane potential
GO:0098909 regulation of cardiac muscle cell action potential involved in regulation of contraction
GO:0140056 organelle localization by membrane tethering
GO:1900121 negative regulation of receptor binding
GO:1903233 regulation of calcium ion-dependent exocytosis of neurotransmitter
GO:1903515 calcium ion transport from cytosol to endoplasmic reticulum
GO:1903779 regulation of cardiac conduction
GO:1990036 calcium ion import into sarcoplasmic reticulum
GO:1990456 mitochondrion-endoplasmic reticulum membrane tethering
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016529 sarcoplasmic reticulum
GO:0031095 platelet dense tubular network membrane
GO:0033017 sarcoplasmic reticulum membrane
GO:0097470 ribbon synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7e7s, PDBe:7e7s, PDBj:7e7s
PDBsum7e7s
PubMed34459010
UniProtP16615|AT2A2_HUMAN Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (Gene Name=ATP2A2)

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