Structure of PDB 7e5e Chain A Binding Site BS02

Receptor Information
>7e5e Chain A (length=338) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RATHRLLLLGAGESGKSTIVKQMRILHVNGFNGKATKVQDIKNNLKEAIE
TIVAAMSNLVPPVELANPENQFRVDYILSVMNVPDFDFPPEFYEHAKALW
EDEGVRACYERSNEYQLIDCAQYFLDKIDVIKQADYVPSDQDLLRCRVLT
SGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVASSSYN
MVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAG
KSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGR
HYCYPHFTCAVDTENIRRVFNDCRDIIQRMHLRQYELL
Ligand information
>7e5e Chain F (length=15) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
YLITFRQWAFNLPCG
Receptor-Ligand Complex Structure
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PDB7e5e State-selective modulation of heterotrimeric G alpha s signaling with macrocyclic peptides.
Resolution1.95 Å
Binding residue
(original residue number in PDB)		R201 L203 R258 E259
Binding residue
(residue number reindexed from 1)		R147 L149 R204 E205
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0019001 guanyl nucleotide binding
GO:0031683 G-protein beta/gamma-subunit complex binding
Biological Process
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:7e5e, PDBe:7e5e, PDBj:7e5e
PDBsum7e5e
PubMed36170854
UniProtP63092|GNAS2_HUMAN Guanine nucleotide-binding protein G(s) subunit alpha isoforms short (Gene Name=GNAS)

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