Structure of PDB 7dy2 Chain A Binding Site BS02

Receptor Information
>7dy2 Chain A (length=464) Species: 1140 (Synechococcus elongatus PCC 7942 = FACHB-805) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AKMRTMIEGFDDISHGGLPIGRSTLVSGTSGTGKTLFSIQFLYNGIIEFD
EPGVFVTFEETPQDIIKNARSFGWDLAKLVDEGKLFILDASPDPDLSALI
ERINYAIQKYRARRVSIDSVTSVFASSVVRRELFRLVARLKQIGATTVMT
TERIEEYGPIARYGVEEFVSDNVVILRNVLEGERRRRTLEILKLRGTSHM
KGEYPFTITDHGINIFPLGLTQRSSNVRVSSGVVRLDEMCGGGFFKDSII
LATGATGTGKTLLVSRFVENACANKERAILFAYEESRAQLLRNAYSWGMD
FEEMERQNLLKIVCAYPESAGLEDHLQIIKSEINDFKPARIAIDSLSALA
RGVSNNAFRQFVIGVTGYAKQEEITGLFTNTSDQFMGAHSITDSHISTIT
DTIILLQYVEIRGEMSRAINVFKMRGSWHDKAIREFMISDKGPDIKDSFR
NFERIISGSPTRIT
Ligand information
Ligand IDATP
InChIInChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChIKeyZKHQWZAMYRWXGA-KQYNXXCUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[CH]3O[CH](CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 10.04O=P(O)(O)OP(=O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@@](=O)(O)O[P@](=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P@](O)(=O)O[P@@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
FormulaC10 H16 N5 O13 P3
NameADENOSINE-5'-TRIPHOSPHATE
ChEMBLCHEMBL14249
DrugBankDB00171
ZINCZINC000004261765
PDB chain7dy2 Chain A Residue 602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7dy2 Elucidation of master allostery essential for circadian clock oscillation in cyanobacteria.
Resolution3.04 Å
Binding residue
(original residue number in PDB)		T290 G291 T292 G293 K294 T295 W331 R451 I472 S473
Binding residue
(residue number reindexed from 1)		T256 G257 T258 G259 K260 T261 W297 R417 I438 S439
Annotation score5
Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
3.6.4.-
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0004674 protein serine/threonine kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0042802 identical protein binding
GO:0044024 histone H2AS1 kinase activity
GO:0046872 metal ion binding
GO:0106310 protein serine kinase activity
Biological Process
GO:0006338 chromatin remodeling
GO:0006355 regulation of DNA-templated transcription
GO:0007623 circadian rhythm
GO:0009649 entrainment of circadian clock
GO:0016310 phosphorylation
GO:0042752 regulation of circadian rhythm
GO:0042754 negative regulation of circadian rhythm
GO:0048511 rhythmic process
GO:0070297 regulation of phosphorelay signal transduction system

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7dy2, PDBe:7dy2, PDBj:7dy2
PDBsum7dy2
PubMed35427168
UniProtQ79PF4|KAIC_SYNE7 Circadian clock oscillator protein KaiC (Gene Name=kaiC)

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