Structure of PDB 7dol Chain A Binding Site BS02

Receptor Information
>7dol Chain A (length=565) Species: 243273 (Mycoplasmoides genitalium G37) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ILTLHYSTGALDGDDAAVITILKRARILYAGNFLVLEYKIVADNPRFYLT
MIVNPDSIPNNLASNTKIAFQIDEYDPDNNLCKVSVQQVLGNNDDPLINI
KAIMLDNSIVFETNDVVEQHANKLSFDTEEQHKAYRQDLTDLAFVTVDPT
TSKDLADAIYVKTIPTGFVLYVAIADVAHYVNRNSEIDIEAKHKTSSIYL
PGHYVVPMLPEQLSNQLCSLNPAQKRYVVVCEISFDNQGRIKTNKLYPAT
IISKNRFSYDQVNKWLNNKSELNCDETVINSLKAAFTLSDLIQAQRQKRG
TIDLSHKETEIVVDEHYFPIKINFLVHDKAETMIENLMVVANETVAWVLT
NNKIALPYRVHPRPSKKKLQSLIETVGELNITKPQFNLDTVTSSQIASWL
NENKDNPSYEIFVILLLRTLGKAFYSVNPLMHFSIGSNHYTHFTSPIRRY
IDLTIHRLLWMHLFTPDQFTDNERDQLKQELEKIADTVNDTEIKIINCER
NANDYLTTLLLSKQIGKTFSGFISAFGIFMRMDENNFDGLIIGDRLEAKL
SEIDFIQKRAILTLI
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain7dol Chain A Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7dol Molecular mechanism of RNase R substrate sensitivity for RNA ribose methylation.
Resolution2.002 Å
Binding residue
(original residue number in PDB)		D276 D285
Binding residue
(residue number reindexed from 1)		D148 D157
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) D276 D282 A284 D285 Y387 R576
Catalytic site (residue number reindexed from 1) D148 D154 A156 D157 Y259 R448
Enzyme Commision number 3.1.13.1: exoribonuclease II.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004518 nuclease activity
GO:0004527 exonuclease activity
GO:0004540 RNA nuclease activity
GO:0008859 exoribonuclease II activity
Biological Process
GO:0006402 mRNA catabolic process
GO:0016070 RNA metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Biological Process
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Cellular Component
External links
PDB RCSB:7dol, PDBe:7dol, PDBj:7dol
PDBsum7dol
PubMed33788943
UniProtP47350|RNR_MYCGE Ribonuclease R (Gene Name=rnr)

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