Structure of PDB 7dok Chain A Binding Site BS02

Receptor Information
>7dok Chain A (length=925) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QSFLNRVCGVSAARLTPCGTGTSTDVVYRAFDIYNDKVAGFAKFLKTNCC
RFQEKDEDDNLIDSYFVVKRHTFSNYQHEETIYNLLKDCPAVAKHDFFKF
RIDGDMVPHISRQRLTKYTMADLVYALRHFDEGNCDTLKEILVTYNCCDD
DYFNKKDWYDFVENPDILRVYANLGERVRQALLKTVQFCDAMRNAGIVGV
LTLDNQDLNGNWYDFGDFIQTTPGSGVPVVDSYYSLLMPILTLTRALTAE
SHVDTDLTKPYIKWDLLKYDFTEERLKLFDRYFKYWDQTYHPNCVNCLDD
RCILHCANFNVLFSTVFPPTSFGPLVRKIFVDGVPFVVSTGYHFRELGVV
HNQDVNLHSSRLSFKELLVYAADPAMHAASGNLLLDKRTTCFSVAALTNN
VAFQTVKPGNFNKDFYDFAVSKGFFKEGSSVELKHFFFAQDGNAAISDYD
YYRYNLPTMCDIRQLLFVVEVVDKYFDCYDGGCINANQVIVNNLDKSAGF
PFNKWGKARLYYDSMSYEDQDALFAYTKRNVIPTITQMNLKYAISAKNRA
RTVAGVSICSTMTNRQFHQKLLKSIAATRGATVVIGTSKFYGGWHNMLKT
VYSDVENPHLMGWDYPKCDRAMPNMLRIMASLVLARKHTTCCSLSHRFYR
LANECAQVLSEMVMCGGSLYVKPGGTSSGDATTAYANSVFNICQAVTANV
NALLSTDGNKIADKYVRNLQHRLYECLYRNRDVDTDFVNEFYAYLRKHFS
MMILSDDAVVCFNSTYASQGLVASIKNFKSVLYYQNNVFMSEAKCWTETD
LTKGPHEFCSQHTMLVKQGDDYVYLPYPDPSRILGAGCFVDDIVKTDGTL
MIERFVSLAIDAYPLTKHPNQEYADVFHLYLQYIRKLHDELTGHMLDMYS
VMLTNDNTSRYWEPEFYEAMYTPHT
Ligand information
>7dok Chain T (length=24) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cccuauaacuuaaucucacauagc
........................
Receptor-Ligand Complex Structure
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PDB7dok Structural basis for repurpose and design of nucleotide drugs for treating COVID-19
Resolution2.73 Å
Binding residue
(original residue number in PDB)		N496 K500 S501 N507 N543 V557 A558 R569 K577 G590 S592 F594 Y595 S682 G683 A685 E857 Y915 F920 M924
Binding residue
(residue number reindexed from 1)		N492 K496 S497 N503 N539 V553 A554 R565 K573 G586 S588 F590 Y591 S678 G679 A681 E853 Y911 F916 M920
Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0005524 ATP binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:7dok, PDBe:7dok, PDBj:7dok
PDBsum7dok
PubMed
UniProtP0DTD1|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep)

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