Structure of PDB 7d21 Chain A Binding Site BS02
Receptor Information
>7d21 Chain A (length=328) Species:
6945
(Ixodes scapularis) [
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WHDLKWPRDLRPLAHHDLLYMGQISEDRGDFNATLRNFLVPRVVGSQKHR
EVREFIVRSLKDLDWDVEEDCFDGQTPHGIKPFCNVIATLNPSACHRLVL
ACHYDSLLHKEGTFIGATDSAVPCAQLLYLARSLNGKLQNQKTRGDGLTL
QLVFFDGEEAFERWSSHDSLYGSRHLAQKWHEDRTSAERLESCLERSEIA
NQIDRMEVMVLLDLLGAENPRFYSYFGETQPVYRRLVNIESRLNDAGLME
LPRRRRRTNYFSNSSTVGFIEDDHIPFLKRSVPIVHIIPSPFPDVWHTLD
DNEQNLHHPTISNLNKIFKAFVSEYLQL
Ligand information
Ligand ID
ZN
InChI
InChI=1S/Zn/q+2
InChIKey
PTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
Software
SMILES
CACTVS 3.341
[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Zn+2]
Formula
Zn
Name
ZINC ION
ChEMBL
CHEMBL1236970
DrugBank
DB14532
ZINC
PDB chain
7d21 Chain A Residue 402 [
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Receptor-Ligand Complex Structure
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PDB
7d21
A Unique Carboxylic-Acid Hydrogen-Bond Network (CAHBN) Confers Glutaminyl Cyclase Activity on M28 Family Enzymes.
Resolution
1.97 Å
Binding residue
(original residue number in PDB)
H128 D144 E183 D238
Binding residue
(residue number reindexed from 1)
H103 D119 E158 D213
Annotation score
1
Enzymatic activity
Enzyme Commision number
2.3.2.5
: glutaminyl-peptide cyclotransferase.
Gene Ontology
Molecular Function
GO:0008270
zinc ion binding
GO:0016603
glutaminyl-peptide cyclotransferase activity
GO:0016746
acyltransferase activity
GO:0046872
metal ion binding
Biological Process
GO:0017186
peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase
Cellular Component
GO:0005576
extracellular region
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Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:7d21
,
PDBe:7d21
,
PDBj:7d21
PDBsum
7d21
PubMed
33774034
UniProt
B7QK46
|QPCT_IXOSC Glutaminyl-peptide cyclotransferase (Gene Name=Qptc)
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