Structure of PDB 7cym Chain A Binding Site BS02

Receptor Information
>7cym Chain A (length=417) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KFSGPLKPMTFSIYEGQEPSQIIFQFKANPPAVTFELTGETDNIFVIERE
GLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDINDNRPT
FLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMIN
NVMYFQINNKTGAISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFS
DTTSVDIIVTENIWKAPKPVEMVENSTDPHPIKITQVRWNDPGAQYSLVD
KEKLPRFPFSIDQEGDIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLE
IHVKVKDINDNPPTCPSPVTVFEVQENERLGNSIGTLTAHDRDEENTANS
FLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLKKQDTPQYNLTIEVS
DKDFKTLCFVQINVIDE
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain7cym Chain A Residue 504 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7cym Mechanism of dimerization and structural features of human LI-cadherin.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		E40 E87 D118 I119 D121 D154
Binding residue
(residue number reindexed from 1)		E15 E62 D93 I94 D96 D129
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
Biological Process
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
GO:0098609 cell-cell adhesion
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7cym, PDBe:7cym, PDBj:7cym
PDBsum7cym
PubMed34364873
UniProtQ12864|CAD17_HUMAN Cadherin-17 (Gene Name=CDH17)

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