Structure of PDB 7cli Chain A Binding Site BS02

Receptor Information
>7cli Chain A (length=292) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ADGPYLVIVEQPKQRGFRFRYGCEGPSHGGLPGASSEKGRKTYPTVKICN
YEGPAKIEVDLVTHSDPPRAHAHSLVGKQCSELGICAVSVGPKDMTAQFN
NLGVLHVTKKNMMGTMIQKLQRQRLRSGLTEAEQRELEQEAKELKKVMDL
SIVRLRFSAFLRASDGSFSLPLKPVISQPIHDSKSPGASNLKISRMDKTA
GSVRGGDEVYLLCDKVQKDDIEVRFYEDDENGWQAFGDFSPTDVHKQYAI
VFRTPPYHKMKIERPVTVFLQLKRKRGGDVSDSKQFTYYPLV
Ligand information
Receptor-Ligand Complex Structure
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PDB7cli Structures of NF-kappa B p52 homodimer-DNA complexes rationalize binding mechanisms and transcription activation.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		R52 R54 S61 H62 G63 K75
Binding residue
(residue number reindexed from 1)		R18 R20 S27 H28 G29 K41
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7cli, PDBe:7cli, PDBj:7cli
PDBsum7cli
PubMed36779700
UniProtQ00653|NFKB2_HUMAN Nuclear factor NF-kappa-B p100 subunit (Gene Name=NFKB2)

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