Structure of PDB 7ckm Chain A Binding Site BS02

Receptor Information
>7ckm Chain A (length=1603) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DEYVQELKGLIRKHIPERCEFGHQKVTFLSQVHPSPLLTEGFKLLSSLVE
LESCEAHACQANTDQRFVDVILSDNGILCPTLPKVIPDGFKLTGKTLILL
ETFVRVNPDEFEKKWKADMSKLLNLKHDLQKSGVTLVPIVDGRSNYNNRF
VADWVIERIRWLLIEILKASKSEDQEYQRLIHSLSNVKLENLEHLKRNSL
DYDERLNESLFIGLKGDIRESTVREELIKLKLWFKDEVFSKGLGKFKLTD
RRELLESLSSLGAHLDSDVSSCPFCNNKLMEIVYNVTFSCVERSNIEKHY
LSVLSLCNKIKGLKVFNTRRNTLLFLDLIMVNLMVDISDSCQDAIESLRK
SGLIVGQMVMLVNDRVLDILEAVKLIRKKIGTNPNWVKNCSKILERSHPE
IWHHLSTLIKQPDFNSLISIAQHLVSDRPIMRYSKICRHKLFQEMSSFEQ
MRLFKTLSSISLSLINSMKTSFSSRLLVNEFGNVRLRECYAQRFYLAESL
VGFLFYQKTGERSRCYSVYLSDNGVMSEQGSFYCDPKRFFLPVFSDEVLA
GMCEEMTSWLDFDTGLMNDTGPILRLLVLAILCSPSKRNQTFLQGLRYFL
MAFANQIHHIDLTSKLVVECKSSSEVVVQRLAVGLFIRLLSGESDASLFF
SRRFKYLLNVSYLCHLITKETPDRLTDQIKCFEKFIEPKVKFGCAVVNPS
LNGKLTVDQEDIMINGLKKFFSKSLRDTEDVQTPGVCKELLNYCVSLFNR
GKLKVSGELKNNPFRIPKLDELGNILSTYDKEKLVSACVSSMAERFKNLD
PDSTDYLILKNLTTQEELSLMYEALTEEQVESFNEIKHDVQVALAKMADV
SLHEVKDFDPDVLPPEVYKELCDAVYKSSEKCNFFLEGVLDVCPLGLLLK
NLTTSSYVDEEYFMCFKYLLIQGHFDQFTNAALRNLCFYSEDSPTEFTSI
SSNSGNLKFGLSYKEQVGSNRELYVGDLNTKLMTRLVEDFSEAVGNSMKY
TCLNSEKEFERAICDMKMAVNNGDLSCSYDHSKWGPTMSPALFLALLQML
ELRTPVDRSKIDLDSVKSILKWHLHKVVEVPINVAEAYCIGSTSLSEEFF
HQTMQLNGQIPSHIMSVLDMGQGILHNTSDLYGLITEQFLCYALDLLYDV
IPVSYTSSDDQITLIKTPSDAAEWLEMICFHEFLSSKLNKFVSPKSVIGT
FVAEFKSRFFVMGEETPLLTKFVAAALHNVKCKTPTQLSETIDTICDQCI
ANGVSTKIVTRISKRVNQLIRYSGYGETPFGAIEDQDVKDWVDGSRGYRL
QRKIEAIFHDDKETSFIRNCARKVFNDIKRGRIFEENLINLIGRGGDEAL
TGFLQYAGCSEQEVNRVLNYRWVNLSSFGDLRLVLRTKLMTVPTLIKTLQ
SKLSRQSSVASGFIGFCKSMGSKCVRDGGFLYIKEVYSGVSACTCEICAL
KPKIIYCNNSLNKVSQFSKPILWDYFSLVLTNACELGEWVFSTVKEPQNN
QNFFWAVKPKVVRQIEDQLGMNHVLQSIRRNYPVLFDEHLTPFMNDLQVS
RTMDSGRLKFLDVCIALDMMNENLGIISHLLKTRDNSVYIVKQSDCALAH
IRQ
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7ckm Chain A Residue 2302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7ckm Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals
Resolution3.37 Å
Binding residue
(original residue number in PDB)		C284 C470 H472
Binding residue
(residue number reindexed from 1)		C272 C437 H439
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.1.-.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0019079 viral genome replication
GO:0039689 negative stranded viral RNA replication
GO:0039694 viral RNA genome replication
GO:0039696 RNA-templated viral transcription
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0044423 virion component

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7ckm, PDBe:7ckm, PDBj:7ckm
PDBsum7ckm
PubMed
UniProtQ6IVU0

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