Structure of PDB 7ch1 Chain A Binding Site BS02

Receptor Information
>7ch1 Chain A (length=640) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PRPRYVVDRAAYSLTLFDDEFEKSAKIKAVVFGLLPVLSWLPKYKIKDYI
IPDLLGGLSGGSIQVPQGMAFALLANLPAVNGLYSSFFPLLTYFFLGGVH
QMVPGTFAVISILVGNICLQLAPESKFQVSYVDTAAMEAERLHVSATLAC
LTAIIQMGLGFMQFGFVAIYLSESFIRGFMTAAGLQILISVLKYIFGLTI
PSYTGPGSIVFTFIDICKNLPHTNIASLIFALISGAFLVLVKELNARYMH
KIRFPIPTEMIVVVVATAISGGCKMPKKYHMQIVGEIQRGFPTPVSPVVS
QWKDMIGTAFSLAIVSYVINLAMGRTLANKHGYDVDSNQEMIALGCSNFF
GSFFKIHVICCALSVTLAVDGAGGKSQVASLCVSLVVMITMLVLGIYLYP
LPKSVLGALIAVNLKNSLKQLTDPYYLWRKSKLDCCIWVVSFLSSFFLSL
PYGVAVGVAFSVLVVVFQTQFRNGYALAQVMDTDIYVNPKTYNRAQDIQG
IKIITYCSPLYFANSEIFRQKVIAKTGMDPQKVLLAKQKLASVPPFVTFH
TLILDMSGVSFVDLMGIKALAKLSSTYGKIGVKVFLVNIHAQVYNDISHG
GVFEDGSLECKHVFPSIHDAVLFAQANADLEQEMFGSMFH
Ligand information
Ligand IDCL
InChIInChI=1S/ClH/h1H/p-1
InChIKeyVEXZGXHMUGYJMC-UHFFFAOYSA-M
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Cl-]
FormulaCl
NameCHLORIDE ION
ChEMBL
DrugBankDB14547
ZINC
PDB chain7ch1 Chain A Residue 802 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7ch1 Structural insights into the gating mechanism of human SLC26A9 mediated by its C-terminal sequence.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		T127 F128 I131 H385 V386
Binding residue
(residue number reindexed from 1)		T106 F107 I110 H357 V358
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005254 chloride channel activity
GO:0005452 solute:inorganic anion antiporter activity
GO:0015106 bicarbonate transmembrane transporter activity
GO:0015108 chloride transmembrane transporter activity
GO:0015116 sulfate transmembrane transporter activity
GO:0019531 oxalate transmembrane transporter activity
GO:0051117 ATPase binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0006820 monoatomic anion transport
GO:0006821 chloride transport
GO:0010628 positive regulation of gene expression
GO:0015701 bicarbonate transport
GO:0019532 oxalate transport
GO:0055085 transmembrane transport
GO:1902358 sulfate transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0000139 Golgi membrane
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0010008 endosome membrane
GO:0012505 endomembrane system
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0070062 extracellular exosome

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7ch1, PDBe:7ch1, PDBj:7ch1
PDBsum7ch1
PubMed32818062
UniProtQ7LBE3|S26A9_HUMAN Solute carrier family 26 member 9 (Gene Name=SLC26A9)

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