Structure of PDB 7cdw Chain A Binding Site BS02

Receptor Information
>7cdw Chain A (length=683) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QKDVLTDLSRVRNFGIMAHIDAGKTTTTERILYYTGINYKIGEVHDERGI
TITSAATTTFWKDNQLNIIDTPGTVEVERNLRVLDGAVAVFDGKEGVEPQ
SEQVWRQADKYDVPRICFVNKMDKIGADFYFSVRTMGERLGANAVPIQLP
VGAEADFEGVVDLVEMNAKVWRGETKLGETYDTVEIPADLAEQAEEYRTK
LLEVVAESDEHLLEKYLGGEELTVDEIKGAIRKLTIASEIYPVLCGSAFK
NKGVQPMLDAVVDYLPSPLDVPPAIGHAPAKEDEEVVRKATTDEPFAALA
FKIATHPFFGKLTYIRVYSGTVESGSQVINATKGKKERLGKLFQMHSNKE
NPVDRASAGHIYAVIGLKDTTTGDTLSDPNQQIVLESMTFPDPVIEVAIE
PKTKSDQEKLSLSIQKLAEEDPTFKVHLDSETGQTVIGGMGELHLDILVD
RMRREFKVEANVGKPQVAYKETIKRLVQNVEYTHKKQTGGSGQFAKVIIN
LEPFTGEEGATYEFESKVTGGRIPREYIPSVDAGAQDAMQYGVLAGYPLV
NLKVTLLDGAYHEVDSSEMAFKIAGSQVLKKAAALAQPVILEPIMAVEVT
TPEDYMGDVIGDLNSRRGQIQAMEERAGARVVRAHVPLSEMFGYVGDLRS
KTQGRANYSMVFDSYSEVPANVSKEIIAKATGE
Ligand information
Ligand IDGDP
InChIInChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
InChIKeyQGWNDRXFNXRZMB-UUOKFMHZSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.6c1nc2c(n1C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
CACTVS 3.385NC1=Nc2n(cnc2C(=O)N1)[C@@H]3O[C@H](CO[P](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
CACTVS 3.385NC1=Nc2n(cnc2C(=O)N1)[CH]3O[CH](CO[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 12.01O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c2N=C(N)NC1=O)C(O)C3O
OpenEye OEToolkits 1.7.6c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
FormulaC10 H15 N5 O11 P2
NameGUANOSINE-5'-DIPHOSPHATE
ChEMBLCHEMBL384759
DrugBankDB04315
ZINCZINC000008215481
PDB chain7cdw Chain B Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7cdw Crystal Structure of Mycobacterium tuberculosis Elongation Factor G1.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		G384 K386
Binding residue
(residue number reindexed from 1)		G366 K368
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0006412 translation
GO:0006414 translational elongation
GO:0032790 ribosome disassembly
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7cdw, PDBe:7cdw, PDBj:7cdw
PDBsum7cdw
PubMed34540889
UniProtP9WNM7|EFG_MYCTU Elongation factor G (Gene Name=fusA)

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