Structure of PDB 7c4b Chain A Binding Site BS02

Receptor Information

>7c4b Chain A (length=297) Species: 185431 (Trypanosoma brucei brucei TREU927)

SSSSMILKYPYRVVDTHEKLKEAVTSLQGARSIALDIEAFCTTDQAKQLG
RISLVQACSDAKPVVFLFDVLTLTPDVFVKDMQSLLSDREIRKLFFDCRR
DVEALSCQLGVKPEGVLDLQVFFTAIQWKLRSVNRRSGMGYVLKSVAGLT
RQEGDSAVQTAMTLGNRPVWDIRPLPDHFLEYAAGDVRHILLLSNYLVGN
KDVPVDVVAVERLTAQYVEHYAVGKPVITEADATPAEVNRAWLERYIGPG
GGCHFCGAKGHTEAECFKKQNGKAKCSFCGEVGHTARNCFKKHPQLL

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 7c4b Chain A Residue 402

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7c4b Structural basis for guide RNA trimming by RNase D ribonuclease in Trypanosoma brucei.
• Resolution: 2.101 Å
• Binding residue (original residue number in PDB): C320 C323 H328 C333
• Binding residue (residue number reindexed from 1): C276 C279 H284 C289
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0000175 3'-5'-RNA exonuclease activity
• GO:0003676 nucleic acid binding
• GO:0008270 zinc ion binding
• GO:0008408 3'-5' exonuclease activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006139 nucleobase-containing compound metabolic process

Cellular Component

• GO:0005739 mitochondrion
• GO:1990923 PET complex

External links

• PDB: RCSB:7c4b, PDBe:7c4b, PDBj:7c4b
• PDBsum: 7c4b
• PubMed: 33332555
• UniProt: Q38DE2