Structure of PDB 7c43 Chain A Binding Site BS02

Receptor Information

>7c43 Chain A (length=295) Species: 185431 (Trypanosoma brucei brucei TREU927) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SSMILKYPYRVVDTHEKLKEAVTSLQGARSIALDIEAFCTTDQAKQLGRI
SLVQACSDAKPVVFLFDVLTLTPDVFVKDMQSLLSDREIRKLFFDCRRDV
EALSCQLGVKPEGVLDLQVFFTAIQWKLRSVNRRSGMGYVLKSVAGLTRQ
EGDSAVQTAMTLGNRPVWDIRPLPDHFLEYAAGDVRHILLLSNYLVGNKD
VPVDVVAVERLTAQYVEHYAVGKPVITEADATPAEVNRAWLERYIGPGGG
CHFCGAKGHTEAECFKKQNGKAKCSFCGEVGHTARNCFKKHPQLL

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

7c43 Chain A Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7c43 Structural basis for guide RNA trimming by RNase D ribonuclease in Trypanosoma brucei.
Resolution	2.3 Å
Binding residue (original residue number in PDB)	C320 C323 H328 C333
Binding residue (residue number reindexed from 1)	C274 C277 H282 C287
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0000175	3'-5'-RNA exonuclease activity
GO:0003676	nucleic acid binding
GO:0008270	zinc ion binding
GO:0008408	3'-5' exonuclease activity
GO:0046872	metal ion binding

	Biological Process
GO:0006139	nucleobase-containing compound metabolic process

	Cellular Component
GO:0005739	mitochondrion
GO:1990923	PET complex

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Molecular Function

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Cellular Component

External links

PDB	RCSB:7c43, PDBe:7c43, PDBj:7c43
PDBsum	7c43
PubMed	33332555
UniProt	Q38DE2

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