Structure of PDB 7c3t Chain A Binding Site BS02

Receptor Information
>7c3t Chain A (length=187) Species: 228410 (Nitrosomonas europaea ATCC 19718) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DALHIGLPPFLVQANNEPRVLAAPEARMGYVLELVRANIAADGGPFAAAV
FERDSGLLIAAGTQRVVPGRCSAAHAEILALSLAQAKLDTHDLSADGLPA
CELVTSAEPCVMCFGAVIWSGVRSLVCAARSDDVEAIGFDEGPRPENWMG
GLEARGITVTTGLLRDAACALLREYNACNGVIYNARC
Ligand information
Ligand IDAZG
InChIInChI=1S/C4H4N6O/c5-4-6-2-1(3(11)7-4)8-10-9-2/h(H4,5,6,7,8,9,10,11)
InChIKeyLPXQRXLUHJKZIE-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c12c(nc(nc1O)N)nn[nH]2
ACDLabs 10.04n1c(O)c2c(nc1N)nnn2
CACTVS 3.341Nc1nc(O)c2[nH]nnc2n1
FormulaC4 H4 N6 O
Name5-AMINO-1H-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDIN-7-OL;
8-AZAGUANINE
ChEMBLCHEMBL374107
DrugBankDB01667
ZINCZINC000096321491
PDB chain7c3t Chain A Residue 202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7c3t Structure guided mutagenesis reveals the substrate determinants of guanine deaminase.
Resolution2.07 Å
Binding residue
(original residue number in PDB)		F48 Q66 H77 A78 E79
Binding residue
(residue number reindexed from 1)		F46 Q64 H75 A76 E77
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
GO:0047974 guanosine deaminase activity
Biological Process
GO:0006152 purine nucleoside catabolic process

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:7c3t, PDBe:7c3t, PDBj:7c3t
PDBsum7c3t
PubMed34010666
UniProtQ82Y41

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