Structure of PDB 7bwc Chain A Binding Site BS02

Receptor Information
>7bwc Chain A (length=464) Species: 7091 (Bombyx mori) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QNETAKRELEEYIADKKAEINPRYRPHYHISPPVGWMNAPNGFSYYKGKF
HLFYQFYPYDSVWGPMHWGHVSSSNLIDWEHLPTALIPETEMCFSGGAVV
HGDDLVLLYTGRVTTDTDPFYNETQYLAFSNDGVNFRKYEGNPVLSYVPD
NSADFRDPKIWKFKDHWYVVIGSSSNKQGRVLLYRSGDLFNWEFLSVLGE
SDGDMGYMWECPDLFELGGKTIFLWSPQGLEPKGDRYKNTYQTGYYIGEL
DYETFEFKTDKYFQELDYGHDFYATQTIQGDGKTYLIGWFNMWEVPHLEE
EDGWAGTTTLVRELQLIGTRITMNPLEGIQDLRTDSVHNGDLEPQQAIEF
GPTAEIILQGCLDQKIELLIQGKEGGLVTTVTWDPEVGKVIVNRSGEVRQ
VEWVPIGKTSWRLFLDASSLELFCGEGEVVFSSRIFSDGDWVVKNSSPQT
LSVEAYRLRRSVPA
Ligand information
Ligand IDFRU
InChIInChI=1S/C6H12O6/c7-1-3-4(9)5(10)6(11,2-8)12-3/h3-5,7-11H,1-2H2/t3-,4-,5+,6-/m1/s1
InChIKeyRFSUNEUAIZKAJO-ARQDHWQXSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04OC1C(O)C(OC1(O)CO)CO
OpenEye OEToolkits 1.5.0C([C@@H]1[C@H]([C@@H]([C@](O1)(CO)O)O)O)O
CACTVS 3.341OC[CH]1O[C](O)(CO)[CH](O)[CH]1O
OpenEye OEToolkits 1.5.0C(C1C(C(C(O1)(CO)O)O)O)O
CACTVS 3.341OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O
FormulaC6 H12 O6
Namebeta-D-fructofuranose;
beta-D-fructose;
D-fructose;
fructose
ChEMBLCHEMBL604608
DrugBank
ZINCZINC000001529270
PDB chain7bwc Chain B Residue 2 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7bwc Structural insight into the substrate specificity of Bombyx mori beta-fructofuranosidase belonging to the glycoside hydrolase family 32.
Resolution1.95 Å
Binding residue
(original residue number in PDB)		N62 Q79 M90 F118 S119 R180 D181 E234 W317
Binding residue
(residue number reindexed from 1)		N38 Q55 M66 F94 S95 R156 D157 E210 W293
Annotation score4
Enzymatic activity
Enzyme Commision number 3.2.1.26: beta-fructofuranosidase.
Gene Ontology
Molecular Function
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004564 beta-fructofuranosidase activity
Biological Process
GO:0005975 carbohydrate metabolic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7bwc, PDBe:7bwc, PDBj:7bwc
PDBsum7bwc
PubMed33132139
UniProtA0A6F8Z6Y2

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