Structure of PDB 7bkq Chain A Binding Site BS02

Receptor Information
>7bkq Chain A (length=640) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LQLRPYQMEVAQPALDGKNIIICLPTGSGKTRVAVYITKDHLDKKKQASE
SGKVIVLVNKVMLAEQLFRKEFNPYLKKWYRIIGLSGDTQLKISFPEVVK
SYDVIISTAQILENSLLNLESGDDDGVQLSDFSLIIIDECHHTNKEAVYN
NIMRRYLKQKLRNNDLKKQNKPAIPLPQILGLTASPGVGAAKKQSEAEKH
ILNICANLDAFTIKTVKENLGQLKHQIKKFVIANPFKEKLLEIMASIQTY
CQKSPMSDFGTQHYEQWAIQMEKKAAKDGNRKDRVCAEHLRKYNEALQIN
DTIRMIDAYSHLETFYTDEKEKKFAVLNDKLDETDEFLMNLFFDNKKMLK
KLAENPEKLIKLRNTILEQFTRSSSRGIIFTKTRQSTYALSQWIMENAKF
AEVGVKAHHLIGAGHSSEVKPMTQTEQKEVISKFRTGEINLLIATTVAEE
GLDIKECNIVIRYGLSTYVLVTEREIVNDFREKMMYKAINRVQNMKPEEY
AHKILELQVQSILEKKMKVKRSIAKQYNDNPSLITLLCKNCSMLVCSGEN
IHVIEKMHHVNMTPEFKGLYIVRENKNGEIICKCGQAWGTMMVHKGLDLP
CLKIRNFVVNFKNNSPKKQYKKWVELPIRFPDLDYSEYCL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7bkq MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		N365 V367 G393 I417 E580 Q581 K726 R728 I755 G756 S761 T789 T790 V791 H974 K1001
Binding residue
(residue number reindexed from 1)		N59 V61 G87 I111 E265 Q266 K382 R384 I411 G412 S417 T445 T446 V447 H594 K621
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:7bkq, PDBe:7bkq, PDBj:7bkq
PDBsum7bkq
PubMed34795277
UniProtQ8R5F7|IFIH1_MOUSE Interferon-induced helicase C domain-containing protein 1 (Gene Name=Ifih1)

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