Structure of PDB 7bg9 Chain A Binding Site BS02

Receptor Information
>7bg9 Chain A (length=913) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RSLLRSHYREVLPLATFVRRLGPQGWRLVQRGDPAAFRALVAQCLVCVPW
CLKELVARVLQRLCERGAKNVLAFGNTVTDALRGSGAWGLLLRRVGDDVL
VHLLARCALFVLVAPSCAYQVCGPPLYQLGPPVYAETKHFLYSSGDKEQL
RPSFLLSSLRPSLTGARRLVETIFLGSRPWMPGTPRRLPRLPQRYWQMRP
LFLELLGNHAQCPYGVLLKTHCPLDPRRLVQLLRQHSSPWQVYGFVRACL
RRLVPPGLWGSRHNERRFLRNTKKFISLGKHAKLSLQELTWKMSVRDCAW
LRRSPGVGCVPAAEHRLREEILAKFLHWLMSVYVVELLRSFFYVTETTFQ
KNRLFFYRKSVWSKLQSIGIRQHLKRVQLRELSEAEVRQHREARPALLTS
RLRFIPKPDGLRPIVNMDYVVGARTFRREKRAERLTSRVKALFSVLNYER
ARRPGLLGASVLGLDDIHRAWRTFVLRVRAQDPPPELYFVKVDVTGAYDT
IPQDRLTEVIASIIKPQNTYCVRRYAVVQKAAHGHVRKAFKSHVSTLTDL
QPYMRQFVAHLQETSPLRDAVVIEQSSSLNEASSGLFDVFLRFMCHHAVR
IRGKSYVQCQGIPQGSILSTLLCSLCYGDMENKLFAGIRRDGLLLRLVDD
FLLVTPHLTHAKTFLRTLVRGVPEYGCVVNLRKTVVNFPVEDEALGGTAF
VQMPAHGLFPWCGLLLDTRTLEVQSDYSSYARTSIRASLTFNRGFKAGRN
MRRKLFGVLRLKCHSLFLDLQVNSLQTVCTNIYKILLLQAYRFHACVLQL
PFHQQVWKNPTFFLRVISDTASLCYSILKAKNAGMSLGAKGAAGPLPSEA
VQWLCHQAFLLKLTRHRVTYVPLLGSLRTAQTQLSRKLPGTTLTALEAAA
NPALPSDFKTILD
Ligand information
>7bg9 Chain B (length=256) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gggugguggccauuuuuugucuaacccuaacugagaagggcguaggcgcc
gugcuuuugcuccccgcgcgcuguuuuucucgcugacuuucagcgggcgg
aaaagccucggccugccgccuuccgagcaaacaaaaaaugucagcugcug
gcccguucgccccgaaccccgccgaggccgcggucggcccggggcuucuc
cggaggcacccacugccaccgcgaagaguugggcucugucagccgcgggu
cucucg
.<<....<<<<<.........................<<<<<<<<<<...
..<<<<<<.....<<<<.<<<<<........(((((((((>>>>>.>>>>
>>>>>>....>>>>>.>>>>>..............))).))))))...>>
>>>......>>.<<<..<<<<<...<<..<<<<<.<<<..<<<<<<....
....>>>.>>>...>>>>>>>>..<<<<.....>>>>.....>>>>>>>.
...>>>
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7bg9 Structure of human telomerase holoenzyme with bound telomeric DNA.
Resolution3.8 Å
Binding residue
(original residue number in PDB)		S12 R19 R30 A49 Q53 H330 L332 Y333 G336 K338 E339 Q340 L341 R342 R351 T355 W371 R377 R378 R381 L382 R385 W387 R466 R470 R489 Q506 W510 K511 S513 V514 R515 C528 V529 P530 A531 H534 R535 R620 R622 I633 V634 N635 D637 L786 G834 I836 T839 K965 G967 R968 R979 V1016 L1017 L1019 H1022 Q1023 K1027 N1028 F1031 K1059 R1105
Binding residue
(residue number reindexed from 1)		S2 R9 R20 A39 Q43 H139 L141 Y142 G145 K147 E148 Q149 L150 R151 R160 T164 W180 R186 R187 R190 L191 R194 W196 R247 R251 R270 Q287 W291 K292 S294 V295 R296 C309 V310 P311 A312 H315 R316 R401 R403 I414 V415 N416 D418 L567 G615 I617 T620 K746 G748 R749 R760 V797 L798 L800 H803 Q804 K808 N809 F812 K840 R886
Enzymatic activity
Enzyme Commision number 2.7.7.49: RNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0001223 transcription coactivator binding
GO:0003677 DNA binding
GO:0003720 telomerase activity
GO:0003723 RNA binding
GO:0003964 RNA-directed DNA polymerase activity
GO:0003968 RNA-dependent RNA polymerase activity
GO:0005515 protein binding
GO:0019865 immunoglobulin binding
GO:0042162 telomeric DNA binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0051087 protein-folding chaperone binding
GO:0070034 telomerase RNA binding
GO:0098680 template-free RNA nucleotidyltransferase
Biological Process
GO:0000723 telomere maintenance
GO:0001172 RNA-templated transcription
GO:0006278 RNA-templated DNA biosynthetic process
GO:0007004 telomere maintenance via telomerase
GO:0007005 mitochondrion organization
GO:0010629 negative regulation of gene expression
GO:0022616 DNA strand elongation
GO:0030177 positive regulation of Wnt signaling pathway
GO:0030422 siRNA processing
GO:0031647 regulation of protein stability
GO:0032092 positive regulation of protein binding
GO:0042635 positive regulation of hair cycle
GO:0043066 negative regulation of apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0045766 positive regulation of angiogenesis
GO:0046326 positive regulation of D-glucose import
GO:0046686 response to cadmium ion
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0070200 establishment of protein localization to telomere
GO:0071456 cellular response to hypoxia
GO:0071897 DNA biosynthetic process
GO:0090399 replicative senescence
GO:0140745 siRNA transcription
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
GO:1902895 positive regulation of miRNA transcription
GO:1903620 positive regulation of transdifferentiation
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
GO:1904751 positive regulation of protein localization to nucleolus
GO:1904754 positive regulation of vascular associated smooth muscle cell migration
GO:2000352 negative regulation of endothelial cell apoptotic process
GO:2000648 positive regulation of stem cell proliferation
GO:2000773 negative regulation of cellular senescence
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0000333 telomerase catalytic core complex
GO:0000781 chromosome, telomeric region
GO:0000783 nuclear telomere cap complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005697 telomerase holoenzyme complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016605 PML body
GO:0016607 nuclear speck
GO:0031379 RNA-directed RNA polymerase complex
GO:0042645 mitochondrial nucleoid
GO:0043231 intracellular membrane-bounded organelle
GO:1990572 TERT-RMRP complex
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7bg9, PDBe:7bg9, PDBj:7bg9
PDBsum7bg9
PubMed33883742
UniProtO14746|TERT_HUMAN Telomerase reverse transcriptase (Gene Name=TERT)

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