Structure of PDB 7bee Chain A Binding Site BS02

Receptor Information

>7bee Chain A (length=378) Species: 9615 (Canis lupus familiaris) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MLSPKAATLAERSAGLAFSLYQAMAKDQAVENILLSPVVVASSLGLVSLG
GKATTASQAKAVLSAEQLRDEEVHAGLGELLRSLSNSTARNVTWKLGSRL
YGPSSVSFAEDFVRSSKQHYNCEHSKINFRDKRSALQSINEWAAQTTDGK
LPEVTKDVERTDGALLVNAMFFKPHWDEKFHHKMVDNRGFMVTRSYTVGV
TMMHRTGLYNYYDDEKEKLQIVEMPLAHKLSSLIILMPHHVEPLERLEKL
LTKEQLKIWMGKMQKKAVAISLPKGVVEVTHDLQKHLAGLGLTEAIDKNK
ADLSRMSGKKDLYLASVFHATAFEWDTEGNPFDQDIYGREELRSPKLFYA
DHPFIFLVRDTQSGSLLFIGRLVRPKGD

Ligand information

>7bee Chain D (length=19) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

PPGPPGPPGPRGFPGPPGP

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7bee Collagen's primary structure determines collagen:HSP47 complex stoichiometry.
Resolution	1.939 Å
Binding residue (original residue number in PDB)	M225 R228 V275 L381 Y383
Binding residue (residue number reindexed from 1)	M191 R194 V241 L347 Y349

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005518	collagen binding

	Cellular Component
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005783	endoplasmic reticulum

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Molecular Function

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Cellular Component

External links

PDB	RCSB:7bee, PDBe:7bee, PDBj:7bee
PDBsum	7bee
PubMed	34487762
UniProt	A0A8I3N7V2

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