Structure of PDB 7auu Chain A Binding Site BS02

Receptor Information
>7auu Chain A (length=144) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NQVYSPVTGARLVAGCICLTPDKKQVLMITSSAHKKRWIVPKGGVEKDEP
NYETTAQRETWEEAGCIGKIVANLGTVEDMRPGGGPPRTEFHFYELEIEN
LLDKFPECHKRHRKLYSYTEAKQNLIDAKRPELLEALNRSAIIK
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain7auu Chain A Residue 202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7auu Multiple substrate recognition by yeast diadenosine and diphosphoinositol polyphosphate phosphohydrolase through phosphate clamping.
Resolution2.45 Å
Binding residue
(original residue number in PDB)		K63 E84
Binding residue
(residue number reindexed from 1)		K42 E63
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.1.10: endopolyphosphatase.
3.6.1.52: diphosphoinositol-polyphosphate diphosphatase.
3.6.1.60: diadenosine hexaphosphate hydrolase (AMP-forming).
Gene Ontology
Molecular Function
GO:0016462 pyrophosphatase activity

View graph for
Molecular Function
External links
PDB RCSB:7auu, PDBe:7auu, PDBj:7auu
PDBsum7auu
PubMed33893105
UniProtQ99321|DDP1_YEAST Diphosphoinositol polyphosphate phosphohydrolase DDP1 (Gene Name=DDP1)

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