Structure of PDB 7aoc Chain A Binding Site BS02

Receptor Information
>7aoc Chain A (length=1394) Species: 284812 (Schizosaccharomyces pombe 972h-) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MNIAQPVSSEIKSVKFGIYDVDDVEKISVKQIVNPVLLDNLNHPTNGGLY
DLALGPYLKNSVCATCHLDERYCPGHFGHIVLPIPAYHPLFFSQMYNLLR
STCLYCHHFKLSKVKVHLFFCRLKLLDYGLLNESEMVENVSLAKDAATLM
RIRDEFVAKSIADSRQLTTLLLHERKKVVRAFYHAISSRKQCDNCQSFSP
NFRKEGFAKIFEIPLSGKNLQFKYMTSTEVRNHLRRLFVKENVVLSRLYP
ASADMFFLQNIAVPPTRFRPASKMGDEVHENIQNELLTRILQSSIQIASL
SKDSTVEERRSRAFELLINAFVQLQHDVNSLIDSNRNPPPGIKQILEKKE
GLFRKHMMGKRVNYAARSVISPDPNIETNEIGVPPVFATKLTYPEPVTLY
NFNEMRNAVINGPHKWPGASHIQNEDGTLISLMPLTIEQRTALANQLLTP
QSNLISSPYSYSRLINTNKKVYRHVRNGDMLILNRQPTLHKPSMMAHKAR
ILPGEKTIRMHYANCNSYNADFDGDEMNMHFPQSTNARSEAQFIANTDSQ
YLVPTSGDPLRGLIQDHVVMGVWLTCKDTFYTRDEYQQLLFQALKPDETG
MYGRIKTLPPAIQRPGIYWTGKQIISSVLLNLKPSDRPGLNLKSKAKVPG
KYWSPDSEEGSVLFDDGELLCGILDKSSFGASAFGLVHSVHELYGPDIAG
RLLSVLSRLFTAYAQMRGFTCRMDDLRLDEQGDNWRRQLLENGKSFGLEA
ASEYVGLSTDSPIALLNANLEEVYRDDEKLQGLDAAMKGKMNGLTSSIIN
KCIPDGLLTKFPYNHMQTMTVSGAKGSNVNVSQISCLLGQQELEGRRVPL
MVSGKSLPSFVPYETSAKSGGFIASRFLTGIAPQEYYFHCMAGREGLIDT
GYLQRCLMKHLEGLCVQYDHTVRDSDGSIVQFHYGEDSLDVTKQKHLTQF
EFSAKNYKSLIQKYKVKSVLSAVDSETASSYAKKALKKPYKYDPVLDKYP
PSRYLGSVSEKFQRAVDEYTQKNPDKLIAESKLDDSLLNESKFKALMQLR
YQQSLVDPGESVGVLASQSIGEPSTQMTLNTNVTLGIPRLREIIMTASAN
IQTPTMTLRLNDGVSDKRASAFCKEVNKLVLSEVVRQVRVTEKTYAIRLD
LYSRDEYQDEYGVLQEEIESTFSNRFLKILNRIIKSYLAKSKQNCKHLDF
DYVNGEWATVELVFPINTEKLLMVSLVEKACSETVIHEIPGITRCFSKPD
TVPKVITEGVNLKAIWEFYNEISMNDIYTNDIAAILRIYGVEAARNAIVH
EVSSVFGVYGIAVDPRHLSLIADYMTFEGGYKAFNRMGIEYNTSPFAKMS
FETTCHFLTEAALRGDVDDLSNPSSRLVVGRVGNFGTGSFDIFT
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7aoc Chain A Residue 1702 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7aoc Conserved strategies of RNA polymerase I hibernation and activation.
Resolution3.84 Å
Binding residue
(original residue number in PDB)		C106 C228 C231
Binding residue
(residue number reindexed from 1)		C106 C192 C195
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001054 RNA polymerase I activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006362 transcription elongation by RNA polymerase I
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005736 RNA polymerase I complex
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7aoc, PDBe:7aoc, PDBj:7aoc
PDBsum7aoc
PubMed33536435
UniProtP15398|RPA1_SCHPO DNA-directed RNA polymerase I subunit rpa1 (Gene Name=rpa1)

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