Structure of PDB 7aml Chain A Binding Site BS02

Receptor Information
>7aml Chain A (length=596) Species: 7955 (Danio rerio) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GLYFPQRLYTENIYVGQQQGSPLLQVISMREFPTERPYFFLCSHRDAFTS
WFHIDEASGVLYLNKTLEWSDFSSLRSGSVRSPKDLTLKVGVSSTPPMKV
MCTILPTVEVKLSFINDTAPSCGQVELSTLCFPEKISNPHITENREPGAL
RQLRRFTHMSICPNYTISYGVVAGSSVPFAVDDSTSELVVTAQVDREEKE
VYHLDIVCMVRTERNLEEVFRSLHVNIYDEDDNSPYVNGTDTEDVLVEFD
RSEGTVFGTLFVYDRDTTPVYPTNQVQNKLVGTLMTNDSWIKNNFAIEHK
FREEKAIFGNVRGTVHEYKLKLSQNLSVTEQRSFLLGYLVNDTTFPGPEG
TVLLHFNVTVLPVPIRFSNVTYSFTVSQKATTYSQIGKVCVENCQKFKGI
DVTYQLEIVDRNITAEAQSCYWAVSLAQNPNDNTGVLYVNDTKVLRRPEC
QELEYVVIAQEQQNKLQAKTQLTVSFQGEADSLRTDEPRFPACAEKRQRG
DCEATRGLGAPTGRCQWRQGRDKGISKRYSTCSPNLGTCPDGYCDAIESK
NISICPQDCSSEAIIGGYERDLYGIKAGHGTCYCFEGKCFCERDEP
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain7aml Chain A Residue 702 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7aml A two-site flexible clamp mechanism for RET-GDNF-GFR alpha 1 assembly reveals both conformational adaptation and strict geometric spacing.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		E164 E218 D250 E251 D253 D287
Binding residue
(residue number reindexed from 1)		E143 E197 D229 E230 D232 D266
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
Biological Process
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7aml, PDBe:7aml, PDBj:7aml
PDBsum7aml
PubMed33484636
UniProtA8E7C6

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