Structure of PDB 7amk Chain A Binding Site BS02

Receptor Information

>7amk Chain A (length=476) Species: 7955 (Danio rerio)

LYFPQRLYTENIYVGQQQGSPLLQVISMREFPTERPYFFLCSHRDAFTSW
FHIDEASGVLYLNKTLEWSDFSSLRSGSVRSPKDLTLKVGVSSTPPMKVM
CTILPTVEVKLSFINDTAPSCGQVELSTLCFPEKISNPHITENREPGALR
QLRRFTHMSICPNYTISYGVVAGSSVPFAVDDSTSELVVTAQVDREEKEV
YHLDIVCMVRTERNLEEVFRSLHVNIYDEDDNSPYVQGTDTEDVLVEFDR
SEGTVFGTLFVYDRDTTPVYPTNQVQNKLVGTLMTQDSWIKNNFAIEHKF
REEKAIFGNVRGTVHEYKLKLSQNLSVTEQRSFLLGYLVNDTTFPGPEGT
VLLHFNVTVLPVPIRFSQVTYSFTVSQKATTYSQIGKVCVENCQKFKGID
VTYQLEIVDRQITAEAQSCYWAVSLAQNPNDNTGVLYVNDTKVLRRPECQ
ELEYVVIAQEQQNKLQAKTQLTVSFQ

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 7amk Chain A Residue 602

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7amk A two-site flexible clamp mechanism for RET-GDNF-GFR alpha 1 assembly reveals both conformational adaptation and strict geometric spacing.
• Resolution: 2.2 Å
• Binding residue (original residue number in PDB): E164 E218 D250 E251 D253 D287
• Binding residue (residue number reindexed from 1): E142 E196 D228 E229 D231 D265
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.7.10.1: receptor protein-tyrosine kinase.

Gene Ontology

Molecular Function

• GO:0005509 calcium ion binding

Biological Process

• GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:7amk, PDBe:7amk, PDBj:7amk
• PDBsum: 7amk
• PubMed: 33484636
• UniProt: A8E7C6