Structure of PDB 7ae3 Chain A Binding Site BS02

Receptor Information
>7ae3 Chain A (length=1370) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KEQFRETDVAKKISHICFGMKSPEEMRQQAHIQVVSKNLYSQDNQHAPLL
YGVLDHRMGTSEKDRPCETCGKNLADCLGHYGYIDLELPCFHVGYFRAVI
GILQMICKTCCHIMLSQEEKKQFLDYLKRPGLTYLQKRGLKKKISDKCRK
KNICHHCGAFNGTVKKCGLLKIIHEKYKTNKKVVDPIVSNFLQSFETAIE
HNKEVEPLLGRAQENLNPLVVLNLFKRIPAEDVPLLLMNPEAGKPSDLIL
TRLLVPPLCIRPSVVNEDDLTMKLTEIIFLNDVIKKHRISGAKTQMIMED
WDFLQLQCALYINSELSGIPLNMAPKKWTRGFVQRLKGKQGRFRGNLSGK
RVDFSGRTVISPDPNLRIDEVAVPVHVAKILTFPEKVNKANINFLRKLVQ
NGPEVHPGANFIQQRHTQMKRFLKYGNREKMAQELKYGDIVERHLIDGDV
VLFNRQPSLHKLSIMAHLARVKPHRTFRFNECVCTPYNADFDGDEMNLHL
PQTEEAKAEALVLMGTKANLVTPRNGEPLIAAIQDFLTGAYLLTLKDTFF
DRAKACQIIASILVGKDEKIKVRLPPPTILKPVTLWTGKQIFSVILRPSD
DNPVRANLRTKGKQYCGKGEDLCANDSYVTIQNSELMSGSMDKGTLGSGS
KNNIFYILLRDWGQNEAADAMSRLARLAPVYLSNRGFSIGIGDVTPGQGL
LKAKYELLNAGYKKCDEYIEALNTGKLQQQPGCTAEETLEALILKELSVI
RDHAGSACLRELDKSNSPLTMALCGSKGSFINISQMIACVGQQAISGSRV
PDGFENRSLPHFEKHSKLPAAKGFVANSFYSGLTPTEFFFHTMAGREGLV
DTAVKTAETGYMQRRLVKSLEDLCSQYDLTVRSSTGDIIQFIYGGDGLDP
AAMEGKDEPLEFKRVLDNIKAVFPCPSEPALSKNELILTTESIMKKSEFL
CCQDSFLQEIKKFIKGVSEKIKKTRDKYGINDNGTTEPRVLYQLDRITPT
QVEKFLETCRDKYMRAQMEPGSAVGALCAQSIGEPGTQMTMNITLGVPRI
KEIINASKAISTPIITAQLDKDDDADYARLVKGRIEKTLLGEISEYIEEV
FLPDDCFILVKLSLERIRLLRLEVNAETVRYSICTSKLRVKPGDVAVHGE
AVVCVTPRENSKSSMYYVLQFLKEDLPKVVVQGIPEVSRAVIHIDEQSGK
EKYKLLVEGDNLRAVMATHGVKGTRTTSNNTYEVEKTLGIEAARTTIINE
IQYTMVNHGMSIDRRHVMLLSDLMTYKGEVLGITRFGLAKMKESVLMLAS
FEKTADHLFDAAYFGQKDSVCGVSECIIMGIPMNIGTGLFKLLHKADRDP
NPPKRPLIFDTNEFHIPLVT
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7ae3 Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		K167 R1159 F1306
Binding residue
(residue number reindexed from 1)		K165 R1139 F1286
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0001056 RNA polymerase III activity
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
GO:0071667 DNA/RNA hybrid binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0032728 positive regulation of interferon-beta production
GO:0042797 tRNA transcription by RNA polymerase III
GO:0045087 innate immune response
GO:0051607 defense response to virus
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005666 RNA polymerase III complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0031981 nuclear lumen
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ae3, PDBe:7ae3, PDBj:7ae3
PDBsum7ae3
PubMed33558764
UniProtO14802|RPC1_HUMAN DNA-directed RNA polymerase III subunit RPC1 (Gene Name=POLR3A)

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