Structure of PDB 7a3v Chain A Binding Site BS02

Receptor Information
>7a3v Chain A (length=371) Species: 264203 (Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DRPRFSFSIAAREGKARTGTIEMKRGVIRTPAFMPVGTALKPETVRATGA
DIILGNTYHLMLRPGAERIAKLGGLHSFMGWDRPILTDSGGYQVMSLSLT
KQSEEGVTFKSHLDGSRHMLSPERSIEIQHLLGSDIVMAFDESTPYPATP
SRAASSMERSMRWAKRSRDAFDSRKEQAENAALFGIQQGSVFENLRQQSA
DALAEIGFDGYAVGGLAVGEGQDEMFRVLDFSVPMLPDDKPHYLMGVGKP
DDIVGAVERGIDMFDSVLPTRSGRNGQAFTWDGPINIRNARFSEDLKPLD
SECHCAVCQKWSRACIHALIRAGEILGAMLMTEHNIAFYQQLMQKIRDSI
SEGRFSQFAQDFRARYFARNS
Ligand information
Ligand IDQXE
InChIInChI=1S/C4H8O3S/c5-4-1-2-8(6,7)3-4/h4-5H,1-3H2/t4-/m1/s1
InChIKeyAMXKVIWWXBYXRS-SCSAIBSYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7C1CS(=O)(=O)C[C@@H]1O
CACTVS 3.385O[CH]1CC[S](=O)(=O)C1
CACTVS 3.385O[C@@H]1CC[S](=O)(=O)C1
OpenEye OEToolkits 2.0.7C1CS(=O)(=O)CC1O
FormulaC4 H8 O3 S
Name3-hydroxythietane-1,1-dioxide;
(3~{R})-1,1-bis(oxidanylidene)thiolan-3-ol
ChEMBL
DrugBank
ZINCZINC000003865985
PDB chain7a3v Chain A Residue 404 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7a3v Targeting a Cryptic Pocket in a Protein-Protein Contact by Disulfide-Induced Rupture of a Homodimeric Interface.
Resolution1.7 Å
Binding residue
(original residue number in PDB)		L54 P56 V59 M93
Binding residue
(residue number reindexed from 1)		L40 P42 V45 M79
Annotation score1
Enzymatic activity
Enzyme Commision number 2.4.2.29: tRNA-guanosine(34) preQ1 transglycosylase.
Gene Ontology
Molecular Function
GO:0008479 tRNA-guanosine(34) queuine transglycosylase activity
GO:0016757 glycosyltransferase activity
GO:0016763 pentosyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0002099 tRNA wobble guanine modification
GO:0006400 tRNA modification
GO:0008033 tRNA processing
GO:0008616 queuosine biosynthetic process
GO:0101030 tRNA-guanine transglycosylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7a3v, PDBe:7a3v, PDBj:7a3v
PDBsum7a3v
PubMed34081441
UniProtP28720|TGT_ZYMMO Queuine tRNA-ribosyltransferase (Gene Name=tgt)

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