Structure of PDB 7a0b Chain A Binding Site BS02

Receptor Information
>7a0b Chain A (length=375) Species: 264203 (Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RPRFSFSIAAREGKARTGTIEMKRGVIRTPAFMPVGTAATVKALKPETVR
ATGADIILGNTYHLMLRPGAERIAKLGGLHSFMGWDRPILTDSGGYQVMS
LSLTKQSEEGVTFKSHLDGSRHMLSPERSIEIQHLLGSDIVMAFDESTPY
PATPSRAASSMERSMRWAKRSRDAFDSRKEQAENAALFGIQQGSVFENLR
QQSADALAEIGFDGYAVGGLAVGEGQDEMFRVLDFSVPMLPDDKPHYLMG
VGKPDDIVGAVERGIDMFDSVLPTRSGRNGQAFTWDGPINIRNARFSEDL
KPLDSECHCAVCQKWSRACIHALIRAGEILGAMLMTEHNIAFYQQLMQKI
RDSISEGRFSQFAQDFRARYFARNS
Ligand information
Ligand IDQTQ
InChIInChI=1S/C4H8O4S/c5-3-1-9(7,8)2-4(3)6/h3-6H,1-2H2/t3-,4-/m0/s1
InChIKeyLDVDYVUZEKIBDP-IMJSIDKUSA-N
SMILES
SoftwareSMILES
CACTVS 3.385O[C@H]1C[S](=O)(=O)C[C@@H]1O
OpenEye OEToolkits 2.0.7C1[C@@H]([C@H](CS1(=O)=O)O)O
CACTVS 3.385O[CH]1C[S](=O)(=O)C[CH]1O
OpenEye OEToolkits 2.0.7C1C(C(CS1(=O)=O)O)O
FormulaC4 H8 O4 S
Name(3~{R},4~{R})-1,1-bis(oxidanylidene)thiolane-3,4-diol
ChEMBL
DrugBank
ZINCZINC000001083909
PDB chain7a0b Chain A Residue 406 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7a0b Targeting a Cryptic Pocket in a Protein-Protein Contact by Disulfide-Induced Rupture of a Homodimeric Interface.
Resolution1.77 Å
Binding residue
(original residue number in PDB)		T47 A49 L54 P56 V59 M93
Binding residue
(residue number reindexed from 1)		T37 A39 L44 P46 V49 M83
Annotation score1
Enzymatic activity
Enzyme Commision number 2.4.2.29: tRNA-guanosine(34) preQ1 transglycosylase.
Gene Ontology
Molecular Function
GO:0008479 tRNA-guanosine(34) queuine transglycosylase activity
GO:0016757 glycosyltransferase activity
GO:0016763 pentosyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0002099 tRNA wobble guanine modification
GO:0006400 tRNA modification
GO:0008033 tRNA processing
GO:0008616 queuosine biosynthetic process
GO:0101030 tRNA-guanine transglycosylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7a0b, PDBe:7a0b, PDBj:7a0b
PDBsum7a0b
PubMed34081441
UniProtP28720|TGT_ZYMMO Queuine tRNA-ribosyltransferase (Gene Name=tgt)

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