Structure of PDB 6zq2 Chain A Binding Site BS02

Receptor Information

>6zq2 Chain A (length=223) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

IVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRL
GEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRV
ASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKS
AYPGQITSNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQK
NKPGVYTKVCNYVSWIKQTIASN

Ligand information

Ligand ID

InChI

InChI=1S/Ca/q+2

InChIKey

BHPQYMZQTOCNFJ-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Ca++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Ca+2]

Formula

Name

CALCIUM ION

PDB chain

6zq2 Chain A Residue 302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6zq2 Cationic trypsin in complex with a derivative of benzamidine
Resolution	1.29 Å
Binding residue (original residue number in PDB)	E70 N72 V75 E80
Binding residue (residue number reindexed from 1)	E52 N54 V57 E62
Annotation score	4

Enzymatic activity

Enzyme Commision number

3.4.21.4: trypsin.

Gene Ontology

	Molecular Function
GO:0004175	endopeptidase activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding
GO:0008236	serine-type peptidase activity
GO:0046872	metal ion binding
GO:0097655	serpin family protein binding

	Biological Process
GO:0006508	proteolysis
GO:0007586	digestion

	Cellular Component
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0097180	serine protease inhibitor complex

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External links

PDB	RCSB:6zq2, PDBe:6zq2, PDBj:6zq2
PDBsum	6zq2
PubMed
UniProt	P00760\|TRY1_BOVIN Serine protease 1 (Gene Name=PRSS1)

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