Structure of PDB 6zpl Chain A Binding Site BS02

Receptor Information
>6zpl Chain A (length=518) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPAF
FMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAF
YYFFSSMTHVLPWAYCNNPWNTHDCAGVLDHSLQRTSPSEEYWRLYVLKL
SDDIGNFGEVRLPLLGCLGVAWLVVFLCLIRGVVYFTATFPYVVLTILFV
RGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQAFYSLGCAWGGLITM
ASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSRV
ADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVT
AIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAA
SFSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPA
IIFFILVFTVIQYQPITYNHYQYPGWAVAIGFLMALSSVLCIPLYAMFRL
ARTDGDTLLQRLKNATKP
Ligand information
Ligand IDNA
InChIInChI=1S/Na/q+1
InChIKeyFKNQFGJONOIPTF-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Na+]
FormulaNa
NameSODIUM ION
ChEMBL
DrugBankDB14516
ZINC
PDB chain6zpl Chain A Residue 702 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6zpl Structural insights into the inhibition of glycine reuptake.
Resolution3.945 Å
Binding residue
(original residue number in PDB)		G115 Y116 V118 G119
Binding residue
(residue number reindexed from 1)		G11 Y12 V14 G15
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:6zpl, PDBe:6zpl, PDBj:6zpl
PDBsum6zpl
PubMed33658720
UniProtP48067|SC6A9_HUMAN Sodium- and chloride-dependent glycine transporter 1 (Gene Name=SLC6A9)

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