Structure of PDB 6zm2 Chain A Binding Site BS02

Receptor Information

>6zm2 Chain A (length=627) Species: 759272 (Thermochaetoides thermophila DSM 1495)

TIQEVRKSLPVYAYRDAFLDAVKEYQVLILVGETGSGKTTQIPQYLHEAG
YTKGNRKIACTQPRRVAAMSVAARVADEMGVRLGHEVGYSIRFEDCTSEK
TILKYMTDGMLLREMVTSPDLADYSCIMIDEAHERTVHTDILLALIKDLT
RARPELRLIISSATLNAEKFSAYFDDAPIFNVPGRVHPVEVYYTSAPESN
YLEAALVTVFQIHATQPEGDILVFLTGQEEIERACERVEEIRRKLGPEII
ALPIYSNMPSEMQAKIFEPTPPGARKVVFSTNIAETSLTIDGIVYVIDSG
YVKENTFSPVGTTGQSTLAVVPCSRAAANQRMGRAGRVKPGKCFRLYTKY
AYLSEMDESPTPEIQRTSLSSVVLQLKALGIDDLLGFDFLDPPPTELLIK
SLNMLYALGALNSAGQLTRVGRQMGEFPTEPMLAKALIAATQEGCVSEVL
TIVSMLGEVGTLFFRPKDKKVHADSARARFTVRDGGDHLTLLNIYNQWVE
AEYSPIWARENFLAQRSLTRARDVRDQLAKLCDRILDGSEASCGGVNNPT
PILRALTAAFFLNAARLNRAGDGYRTLKNNITVYVHPSSVVRGMDPPPKV
IIYHELVVTSKEYVRSVIPVEPRWLSE

Ligand information

• Ligand ID: BEF
• InChI: InChI=1S/Be.3FH/h;3*1H/q+2;;;/p-3
• InChIKey: OGIAHMCCNXDTIE-UHFFFAOYSA-K
• SMILES:
  OpenEye OEToolkits 1.5.0: [Be-](F)(F)F
  ACDLabs 10.04
  CACTVS 3.341: F[Be-](F)F
• Formula: Be F3
• Name: BERYLLIUM TRIFLUORIDE ION
• PDB chain: 6zm2 Chain A Residue 1101

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6zm2 The structure of Prp2 bound to RNA and ADP-BeF 3 - reveals structural features important for RNA unwinding by DEAH-box ATPases.
• Resolution: 2.1 Å
• Binding residue (original residue number in PDB): T322 K326 R625 R628
• Binding residue (residue number reindexed from 1): T34 K38 R334 R337
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.6.4.13: RNA helicase.

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0005524 ATP binding

External links

• PDB: RCSB:6zm2, PDBe:6zm2, PDBj:6zm2
• PDBsum: 6zm2
• PubMed: 33825710
• UniProt: G0SEG4