Structure of PDB 6z8k Chain A Binding Site BS02

Receptor Information

>6z8k Chain A (length=2158)

MDYQEYQQFLARINTARDACVAKDIDVDLLMARHDYFGRELCKSLNIEYR
NDVPFIDIILDIRPEVDPLTIDAPHITPDNYLYINNVLYIIDYKVSVSNE
SSVITYDKYYELTRDISDRLSIPIEIVIIRIDPVSRDLHINSDRFKELYP
TIVVDINFNQFFDLKQLLYEKFGDDEEFLLKVAHGDFTLTAPWCKTGCPE
FWKHPIYKEFKMSMPVPERRLFEESVKFNAYESERWNTNLVKIREYTKKD
YSEHISKSAKNIFLASGFYKQPNKNEISEGWTLMVERVQDQREISKSLHD
QKPSIHFIWGAHNPGNSNNATFKLILLSKSLQSIKGISTYTEAFKSLGKM
MDIGDKAIEYEEFCMSLKSKARSSWKQIMNKKLEPKQINNALVLWEQQFM
INNDLIDKSEKLKLFKNFCGIGKSKPKILDFDDANMYLASLTMMEQSKKI
LSKSNGLKPDNFILNEFGSRIKDANKETYDNMHKIFETGYWQCISDFSTL
MKNILSVSQYNRHNTFRIAMCANNNVFAIVFPATVVYSIIVLHKEEENIF
NPGCLHGTFKCMNGYISISRAIRLDKERCQRIVSSPGLFLTTCLLFKHDN
PTLVMSDIMNFSIYTSLSITKSVLSLTEPARYMIMNSLAISSNVKDYIAE
KFSPYTKTLFSVYMTRLIKNACFDAYDQRQRVQLRDIYLSDYDITQKGIK
DNRELTSIWFPGSVTLKEYLTQIYLPFYFNAKGLHEKHHVMVDLAKTILE
IECEQRENIKEIWSTNCTKQTVNLKILIHSLCKNLLADTSRHNHLRNRIE
NRNNFRRSITTISTFTSSKSCLKIGDFRKEKELQSVKQKKILEVQSRKNY
EMLRNAMPNYTDYISTKVFDRLYELLDKKVLTDKPVIEQIMDMMIDHKKF
YFTFFNKGQKTSKDREIFVGEYEAKMCMYAVERIAKERCKLNPDEMISEP
GDGKLKVLEQKSEQEIRFLVETTRQKNREIDEAIELGKIEKLSLGKAKGL
KMEINADMSKWSAQDVFYKYFWLIALDPILYPQEKERILYFMCNYMDKEL
ILPDELLFNLLDQKVAYQNDIIATMTNQLNSNTVLIKRNWLQGNFNYTSS
YVHSCAMSVYKEILKEAITLLDGSILVNSLVHSDDNQTSITIVQDKMEND
KIIDFAMKEFERACLTFGCQANMKKTYVTNCIKEFVSLFNLYGEPFSIYG
RFLLTSVGDCAYIGPYEDLASRISSAQTAIKHGCPPSLAWVSIAISHWMT
SLTYNMLPGQSNDPIDYFPAENRKDIPIELNGVLDAPLSMISTVGLESGN
LYFLIKLLSKYTPVMQKRESVVNQIAEVKNWKVEDLTDNEIFRLKILRYL
VLDAEMDPSDIMGETSDMRGRSILTPRKFTTAGSLRKLYSFSKYQDRLSS
PGGMVELFTYLLEKPELLVTKGEDMKDYMESVIFRYNSKRFKESLSIQNP
AQLFIEQILFSHKPVIDFSGIRDKYINLGKVTFTEAYRLLMRDLSSLELT
NDDIQVIYSYIILNDPMMITIANTHILSIYGSPQRRMGMSCSTMPEFRNL
KLIHHSPALVLRAYSKNNPDPTEMARDLVHLKEFVENTNLEEKMKVRIAM
NEAEKGQRDIVFELKEMTRFYQVCYEYVKSHKIKVFILPAKSYTTTDFCS
LMQGNLIKDKEWYTVHYLKQILSGGHKAIMQHNATSEQNIAFECFKLITH
FADSFIDSLSRSAFLQLIIDEFSYKDVKVSKLYDIIKNGYNRTDFIPLLF
RTGDLRQADLDKYDAMKSHERVTWNDWINLTITGYNRSITIIGEDNKLTY
AELCLTRKTPENITISGRKLLGSRHGLKFENMSKIQNYYITYRKKDRHQF
VYQIHSHESITRRNEEHMAIRTRIYNEITPVCVVNVAEVDGDQRILIRSL
DYLNNDIFSLSRIKVGLDEFATIKKAHFSKMVSFEGPPIKTGLLDLTELM
KSQDLLNLNYDNIRNSNLISFSKLICCEGSDNINDGLEFLSDDPMNFTEG
EAIHSTPIFNIYYSKRGERHMTYRNAIKLLIERETKIFEEAFTFSENGFI
SPENLGCLEAVVSLIKLLKTNEWSTVIDKCIHICLIKNGMDHMYHSFDVP
KCFMGNPITRDINWVMFREFINSLPGTDIPPWNVMTENFKKKCIALINSK
FSEFTKLM

Ligand information

>6z8k Chain H (length=11)

aguacacuacu

...........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6z8k Pre-initiation and elongation structures of full-length La Crosse virus polymerase reveal functionally important conformational changes.
• Resolution: 3.02 Å
• Binding residue (original residue number in PDB): H312 N313 N318 K368 R372 I378 K381 K382 L383 W395 E396 L471 K472 N517 S520 V521 Y524 R526 R531 C535 A536 N537 N538 L1512 H1515 K1516
• Binding residue (residue number reindexed from 1): H312 N313 N318 K368 R372 I378 K381 K382 L383 W395 E396 L457 K458 N503 S506 V507 Y510 R512 R517 C521 A522 N523 N524 L1459 H1462 K1463

Enzymatic activity

• Enzyme Commision number: 2.7.7.48: RNA-directed RNA polymerase.
  3.1.-.-

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0003723 RNA binding
• GO:0003968 RNA-dependent RNA polymerase activity
• GO:0016787 hydrolase activity
• GO:0034062 5'-3' RNA polymerase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0001172 RNA-templated transcription
• GO:0006351 DNA-templated transcription
• GO:0019079 viral genome replication
• GO:0039694 viral RNA genome replication

Cellular Component

• GO:0044165 host cell endoplasmic reticulum
• GO:0044172 host cell endoplasmic reticulum-Golgi intermediate compartment
• GO:0044177 host cell Golgi apparatus
• GO:0044423 virion component

External links

• PDB: RCSB:6z8k, PDBe:6z8k, PDBj:6z8k
• PDBsum: 6z8k
• PubMed: 32681014
• UniProt: A5HC98|L_BUNLC RNA-directed RNA polymerase L (Gene Name=L)