Structure of PDB 6yw2 Chain A Binding Site BS02

Receptor Information

>6yw2 Chain A (length=209) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

TKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGK
FTDGIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRT
KAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIF
PEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADER
ARAKVKYLT

Ligand information

Ligand ID

InChI

InChI=1S/Mn/q+2

InChIKey

WAEMQWOKJMHJLA-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mn+2]
CACTVS 3.341	[Mn++]

Formula

Name

MANGANESE (II) ION

PDB chain

6yw2 Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6yw2 Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2.
Resolution	2.14 Å
Binding residue (original residue number in PDB)	H313 D315 H374
Binding residue (residue number reindexed from 1)	H117 D119 H178
Annotation score	1

Enzymatic activity

Enzyme Commision number

1.14.11.29: hypoxia-inducible factor-proline dioxygenase.

Gene Ontology

	Molecular Function
GO:0005506	iron ion binding
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0031418	L-ascorbic acid binding

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Molecular Function

External links

PDB	RCSB:6yw2, PDBe:6yw2, PDBj:6yw2
PDBsum	6yw2
PubMed	33319810
UniProt	Q9GZT9\|EGLN1_HUMAN Egl nine homolog 1 (Gene Name=EGLN1)

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