Structure of PDB 6yii Chain A Binding Site BS02

Receptor Information

>6yii Chain A (length=473) Species: 287 (Pseudomonas aeruginosa)

MSKSWNHDRAAKHIDQKIADVEEITIKDYVRDMSLESIPTSTAYRVDGVH
MYADIMNLEDMLNITAVEGTECHKRTLRFLDQHYRAVKRILNKVDARRVD
FHSQRLHSLFTKPYNTESGAETKRVQRAVATAQLIIDVLAETGDDDEQIP
AAKVRIGIDTGLALAVNNGRSGYREPLFLGDPANHAAKLASNNKARGIYL
TNNARKAIGLAESDEPEKSALTAIEIKACQDAAKLDVTSDEIVEEWREDL
KKNPIGGYQFSRQTPPLRDMDIYSLTPANSKRQEMVSLYADIDGFTAYVA
DHINEKTDDVVRTLHVIRSELERVVTSDFEGRRVRFIGDCVQALSCDGTA
HTTDEEKSVSEATRLAGALRSSFNLAIERLNAEGIETGDLGLAIGFDLGP
IAVTRLGAKGNRVRCAIGRSVIESEKRQCACSGVETAIGQVAYDAASKAV
QNLFGKSRKTSHLDYNEATEALA

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 6yii Chain A Residue 603

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6yii Crystal structure of a class III adenylyl cyclase-like ATP-binding protein from Pseudomonas aeruginosa.
• Resolution: 1.44 Å
• Binding residue (original residue number in PDB): D291 I292 D339
• Binding residue (residue number reindexed from 1): D291 I292 D339
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 4.6.1.26: uridylate cyclase.

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0004016 adenylate cyclase activity
• GO:0016829 lyase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0009190 cyclic nucleotide biosynthetic process
• GO:0035556 intracellular signal transduction
• GO:0051607 defense response to virus

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:6yii, PDBe:6yii, PDBj:6yii
• PDBsum: 6yii
• PubMed: 32454240
• UniProt: P0DV40|PYCC_PSEAI Uridylate cyclase (Gene Name=pycC)