Structure of PDB 6yhr Chain A Binding Site BS02

Receptor Information
>6yhr Chain A (length=541) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGK
SLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENV
LTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWG
HDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITC
TGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMT
QQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMG
INKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNR
HLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASL
GIMGTEKCCDNCRSRLDHCYSMDTSWDFGPQAFKLLSAVDILGEKFGIGL
PILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEV
SRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPK
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6yhr Chain A Residue 1202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6yhr Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		C908 C935 C936 C939
Binding residue
(residue number reindexed from 1)		C381 C408 C409 C412
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.-.-
5.6.2.4: DNA 3'-5' helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0043138 3'-5' DNA helicase activity
Biological Process
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006310 DNA recombination

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Molecular Function
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Biological Process
External links
PDB RCSB:6yhr, PDBe:6yhr, PDBj:6yhr
PDBsum6yhr
PubMed33199508
UniProtQ14191|WRN_HUMAN Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (Gene Name=WRN)

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