Structure of PDB 6ydx Chain A Binding Site BS02

Receptor Information
>6ydx Chain A (length=856) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NGKLFPWAQIRLPTAVVPLRYELSLHPNLTSMTFRGSVTISVQALQVTWN
IILHSTGHNISRVTFMSAVSSQEKQAEILEYAYHGQIAIVAPEALLAGHN
YTLKIEYSANISSSYYGFYGFSYTDESNEKKYFAATQFEPLAARSAFPCF
DEPAFKATFIIKIIRDEQYTALSNMPKKSSGLVQDEFSESVKMSTYLVAF
IVGEMKNLSQDVNGTLVSIYAVPEKIGQVHYALETTVKLLEFFQNYFEIQ
YPLKKLDLVAIPDFEAGAMENWGLLTFREETLLYDSNTSSMADRKLVTKI
IAHELAHQWFGNLVTMKWWNDLWLNEGFATFMEYFSLEKIFKELSSYEDF
LDARFKTMKKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKGSSLLLMLKT
YLSEDVFQHAVVLYLHNHSYASIQSDDLWDSFNEVTNQTLDVKRMMKTWT
LQKGFPLVTVQKKGKELFIQQERFFLYLWHIPLSYVTEGRNYSKYQSVSL
LDKKSGVINLTEEVLWVKVNINMNGYYIVHYADDDWEALIHQLKINPYVL
SDKDRANLINNIFELAGLGKVPLKRAFDLINYLGNENHTAPITEALFQTD
LIYNLLEKLGYMDLASRLVTRVFKLLQNQIQQQTWTDEGTPSMRELRSAL
LEFACTHNLGNCSTTAMKLFDDWMASNGTQSLPTDVMTTVFKVGAKTDKG
WSFLLGKYISIGSEAEKNKILEALASSEDVRKLYWLMKSSLNGDNFRTQK
LSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLGSYTIQNIVAGSTYL
FSTKTHLSEVQAFFENQSEATFRLRCVQEALEVIQLNIQWMEKNLKSLTW
WLRTET
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6ydx Chain A Residue 1102 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6ydx Structural Basis of Inhibition of Insulin-Regulated Aminopeptidase by a Macrocyclic Peptidic Inhibitor.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		H464 H468 E487
Binding residue
(residue number reindexed from 1)		H303 H307 E326
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) E431 H464 E465 H468 E487 E541 Y549
Catalytic site (residue number reindexed from 1) E270 H303 E304 H307 E326 E380 Y388
Enzyme Commision number 3.4.11.3: cystinyl aminopeptidase.
Gene Ontology
Molecular Function
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6ydx, PDBe:6ydx, PDBj:6ydx
PDBsum6ydx
PubMed32676150
UniProtQ9UIQ6|LCAP_HUMAN Leucyl-cystinyl aminopeptidase (Gene Name=LNPEP)

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