Structure of PDB 6yd5 Chain A Binding Site BS02

Receptor Information
>6yd5 Chain A (length=307) Species: 1280 (Staphylococcus aureus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GHMATLKVIGVGGGGNNAVNRMIDHGMNNVEFIAINTDGQALNLSKAESK
IQIGEKLTRGLGAGANPEIGKKAAEESREQIEDAIQGADMVFVTSGMGGG
TGTGAAPVVAKIAKEMGALTVGVVTRPFSFEGRKRQTQAAAGVEAMKAAV
DTLIVIPNDRLLDIVDKSTPMMEAFKEADNVLRQGVQGISDLIAVSGEVN
LDFADVKTIMSNQGSALMGIGVSSGENRAVEAAKKAISSPLLETSIVGAQ
GVLMNITGGESLSLFEAQEAADIVQDAADEDVNMIFGTVINPELQDEIVV
TVIATGF
Ligand information
Ligand IDMB3
InChIInChI=1S/C5H9NO/c1-6-4-2-3-5(6)7/h2-4H2,1H3
InChIKeySECXISVLQFMRJM-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.370
OpenEye OEToolkits 1.7.0		CN1CCCC1=O
ACDLabs 12.01O=C1N(C)CCC1
FormulaC5 H9 N O
Name1-methylpyrrolidin-2-one
ChEMBLCHEMBL12543
DrugBankDB12521
ZINCZINC000003860621
PDB chain6yd5 Chain A Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6yd5 Targeting the FtsZ Allosteric Binding Site with a Novel Fluorescence Polarization Screen, Cytological and Structural Approaches for Antibacterial Discovery.
Resolution1.55 Å
Binding residue
(original residue number in PDB)		G22 T102 S103 T133
Binding residue
(residue number reindexed from 1)		G14 T94 S95 T125
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:6yd5, PDBe:6yd5, PDBj:6yd5
PDBsum6yd5
PubMed33908781
UniProtQ2FZ89|FTSZ_STAA8 Cell division protein FtsZ (Gene Name=ftsZ)

[Back to BioLiP]