Structure of PDB 6y3j Chain A Binding Site BS02

Receptor Information
>6y3j Chain A (length=227) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EPEPEQVIKNYTEELKVPPDEDCIICMEKLSTASGYSDVTDSKAIGSLAV
GHLTKCSHAFHLLCLLAMYCNGNKDGSLQCPSCKTIYGEKTGTQPQGKME
VLRFQMSLPGHEDCGTILIVYSIPHGIQGPEHPNPGKPFTARGFPRQCYL
PDNAQGRKVLELLKVAWKRRLIFTVGTSSTTGETDTVVWNEIHHKTEMDR
NITGHGYPDPNYLQNVLAELAAQGVTE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6y3j Chain A Residue 702 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6y3j DELTEX2 C-terminal domain recognizes and recruits ADP-ribosylated proteins for ubiquitination.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		C445 H447 C469 C472
Binding residue
(residue number reindexed from 1)		C56 H58 C80 C83
Annotation score4
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0046872 metal ion binding
Biological Process
GO:0007219 Notch signaling pathway
GO:0016567 protein ubiquitination

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Molecular Function
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Biological Process
External links
PDB RCSB:6y3j, PDBe:6y3j, PDBj:6y3j
PDBsum6y3j
PubMed32937373
UniProtQ86UW9|DTX2_HUMAN Probable E3 ubiquitin-protein ligase DTX2 (Gene Name=DTX2)

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