Structure of PDB 6y12 Chain A Binding Site BS02

Receptor Information
>6y12 Chain A (length=330) Species: 1960 (Streptomyces vinaceus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VRPWSEFRLTPAEAAAAAALAARCAQRYDETDGPEFLLDAPVIAHELPRR
LRTFMARARLDAWPHALVVRGNPVDDAALGSTPVHWRTARTPGSRPLSFL
LMLYAGLLGDVFGWATQQDGRVVTDVLPIKGGEHTLVSSSSRQELGWHTE
DAFSPYRADYVGLLSLRNPDGVATTLAGVPLDDLDERTLDVLFQERFLIR
PDDSHLQVNNSVEFEGIAQAADRPEPVAILTGHRAAPHLRVDGDFSAPAE
GDEEAAAALGTLRKLIDASLYELVLDQGDVAFIDNRRAVHGRRAFQPRYD
GRDRWLKRINITRDLHRSRKAWAGDSRVLG
Ligand information
Ligand IDZZU
InChIInChI=1S/C6H14N4O3/c7-4(5(12)13)3(11)1-2-10-6(8)9/h3-4,11H,1-2,7H2,(H,12,13)(H4,8,9,10)/t3-,4-/m0/s1
InChIKeyVIDUVSPOWYVZIC-IMJSIDKUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.6.1C(CNC(=N)N)C(C(C(=O)O)N)O
ACDLabs 10.04O=C(O)C(N)C(O)CCNC(=[N@H])N
CACTVS 3.352N[CH]([CH](O)CCNC(N)=N)C(O)=O
CACTVS 3.352N[C@@H]([C@@H](O)CCNC(N)=N)C(O)=O
OpenEye OEToolkits 1.6.1C(CNC(=N)N)[C@@H]([C@@H](C(=O)O)N)O
FormulaC6 H14 N4 O3
Name(2S,3S)-3-HYDROXYARGININE
ChEMBL
DrugBank
ZINCZINC000013352215
PDB chain6y12 Chain A Residue 403 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6y12 Anaerobic fixed-target serial crystallography.
Resolution1.7 Å
Binding residue
(original residue number in PDB)		L156 V157 S158 L165 H168 E170 D222 S224 D268 D270 R334
Binding residue
(residue number reindexed from 1)		L136 V137 S138 L145 H148 E150 D202 S204 D242 D244 R308
Annotation score5
Enzymatic activity
Enzyme Commision number 1.14.11.41: L-arginine hydroxylase.
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0016491 oxidoreductase activity
GO:0016706 2-oxoglutarate-dependent dioxygenase activity
GO:0046872 metal ion binding
GO:0102525 2-oxoglutarate, L-arginine oxygenase (succinate-forming) activity
Biological Process
GO:0017000 antibiotic biosynthetic process
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6y12, PDBe:6y12, PDBj:6y12
PDBsum6y12
PubMed32939282
UniProtQ6WZB0|ARGHX_STRVI Alpha-ketoglutarate-dependent L-arginine hydroxylase (Gene Name=vioC)

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