Structure of PDB 6xpe Chain A Binding Site BS02

Receptor Information
>6xpe Chain A (length=277) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HCHANEYAYAKWKLCSASAICFIFMIAAHLLIDLTSFLLSLFSLWLSSKP
PSKRLTFGWHRAEILGALLSILCIWVVTGVLVYLACERLLYPDYQATVMI
IVSSCAVAANIVLTVVLHQANASVRAAFVHALGDLFQSISVLISALIIYF
KPEYKIADPICTFIFSILVLASTITILKDFSILLMEGVPKSLNYSGVKEL
ILAVDGVLSVHSLHIWSLTMNQVILSAHVATAASRDSQVVRREIAKALSK
SFTMHSLTIQMESPVDQDCLFCEDPCD
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6xpe Chain A Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6xpe Cryo-EM structures of human ZnT8 in both outward- and inward-facing conformations.
Resolution4.1 Å
Binding residue
(original residue number in PDB)		H301 H318 E352
Binding residue
(residue number reindexed from 1)		H211 H228 E262
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008324 monoatomic cation transmembrane transporter activity
Biological Process
GO:0006812 monoatomic cation transport
GO:0055085 transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6xpe, PDBe:6xpe, PDBj:6xpe
PDBsum6xpe
PubMed32723473
UniProtQ8IWU4|ZNT8_HUMAN Proton-coupled zinc antiporter SLC30A8 (Gene Name=SLC30A8)

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